PMID: 9159598Apr 1, 1997Paper

Atrial natriuretic peptides predict mortality in the elderly

Journal of Internal Medicine
T WallénK Nakao

Abstract

To ascertain whether atrial natriuretic peptides could be used as prospective and independent predictors of total mortality in an elderly population. Atrial natriuretic peptides, ANP(1-98) and ANP(99-126), were measured in 541 subjects from the 85-year-old population of Gothenburg, Sweden. Before the study cardiovascular disorders such as congestive heart failure, ischaemic heart disease, hypertension and atrial fibrillation were defined. Total mortality was recorded during the prospective 60-month follow-up period. Individuals aged 85 years from the population of Gothenburg, Sweden, were visited once at home and made one visit to Vasa Hospital. Sixty-month mortality in relation to circulating concentrations of atrial natriuretic peptides. Circulating concentrations of ANP(1-98) and ANP(99-126) were significantly correlated with 60-month mortality in the total study population (ANP(1-98), P < 0.001: ANP(99-126), P < 0.01). In subjects with cardiovascular disorders, 60-month mortality was significantly correlated with increased concentrations of ANP(1-98) (P < 0.01) and ANP(99-126) (P < 0.05). In subjects with no defined cardiovascular disorder, 60-month mortality was significantly correlated with increased ANP(1-98) concentrati...Continue Reading

Citations

May 15, 2002·Progress in Cardiovascular Diseases·Martin R Cowie, Gustavo F Mendez
Nov 7, 2003·International Journal of Cardiology·Motoyuki Nakamura, Katsuhiko Hiramori
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
Feb 13, 2001·European Journal of Heart Failure·R KlemolaM Laine
Nov 9, 2005·Journal of the American Geriatrics Society·Miles D WithamMarion E T McMurdo
Dec 27, 2005·Expert Review of Cardiovascular Therapy·Roy S Gardner, Theresa A McDonagh
Sep 13, 2002·Microscopy Research and Technique·Magnus Hansson
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·G A Sagnella
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ingegerd Odar-CederlöfCarl M Kjellstrand

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