Atrial systole enhances intraventricular filling flow propagation during increasing heart rate

Journal of Biomechanics
Arvind SanthanakrishnanAjit P Yoganathan

Abstract

Diastolic fluid dynamics in the left ventricle (LV) has been examined in multiple clinical studies for understanding cardiac function in healthy humans and developing diagnostic measures in disease conditions. The question of how intraventricular filling vortex flow pattern is affected by increasing heart rate (HR) is still unanswered. Previous studies on healthy subjects have shown a correlation between increasing HR and diminished E/A ratio of transmitral peak velocities during early filling (E-wave) to atrial systole (A-wave). We hypothesize that with increasing HR under constant E/A ratio, E-wave contribution to intraventricular vortex propagation is diminished. A physiologic in vitro flow phantom consisting of a LV physical model was used for this study. HR was varied across 70, 100 and 120 beats per minute (bpm) with E/A of 1.1-1.2. Intraventricular flow patterns were characterized using 2D particle image velocimetry measured across three parallel longitudinal (apical-basal) planes in the LV. A pair of counter-rotating vortices was observed during E-wave across all HRs. With increasing HR, diminished vortex propagation occurred during E-wave and atrial systole was found to amplify secondary vorticity production. The diast...Continue Reading

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Citations

Aug 9, 2019·Echocardiography·Xiaoxia ZhangHaibin Zhang
Jan 17, 2017·Annals of Biomedical Engineering·Ikechukwu OkaforAjit P Yoganathan
May 21, 2019·Frontiers in Physiology·Yolanda BenitoJavier Bermejo
Jul 1, 2020·Journal of Biomechanical Engineering·Milad SamaeeArvind Santhanakrishnan

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