Atrophied Thymus, a Tumor Reservoir for Harboring Melanoma Cells

Molecular Cancer Research : MCR
Olga SizovaDong-Ming Su

Abstract

Tumor metastatic relapse is the primary cause for cancer-associated mortality. Metastatic relapse is believed to arise from quantities of tumor cells that are below detectable thresholds, which are able to resist radio/chemotherapy by obtaining a dormant state and hiding in certain organs, i.e., tumor reservoirs. The thymus, a central T-cell immune organ, has been suggested to be a premetastatic tumor reservoir for B-lymphoma cells. However, it remains unknown whether the thymus is able to harbor nonlymphoid solid tumor cells, and whether chemotherapy can thoroughly eliminate cancer cells in the thymus. If chemotherapy is not able to eliminate these cells in the thymus, then what processes allow for this? Melanoma cell-inoculated and genotoxic doxorubicin-treated mouse model systems were used to determine that the thymus, particularly the atrophied thymus, was able to harbor blood stream-circulating melanoma cells. In addition, a chemotherapy-induced DNA-damage response triggered p53 activation in nonmalignant thymic cells, which in turn resulted in thymocyte death and thymic epithelial cell senescence to develop an inflammatory thymic microenvironment. This inflammatory condition induced thymic-harbored minimal tumor cells to ...Continue Reading

References

May 19, 2001·European Journal of Biochemistry·K ItahanaJ Campisi
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 4, 2003·Current Opinion in Cell Biology·Kelly M Boatright, Guy S Salvesen
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Jul 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna M MüllerHans-Reimer Rodewald
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 8, 2006·Nature Medicine·Patricia S Steeg
Oct 25, 2007·Nature Reviews. Cancer·Julio A Aguirre-Ghiso
Apr 25, 2008·Current Protocols in Immunology·W W Overwijk, N P Restifo
Jun 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine E Eyler, Jeremy N Rich
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Dec 4, 2009·The Journal of Biological Chemistry·Lili ChengDong-Ming Su
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
Jul 30, 2010·Trends in Molecular Medicine·Klaus Pantel, Catherine Alix-Panabières
Oct 30, 2010·Cell·Luke A Gilbert, Michael T Hemann
Nov 26, 2010·Current Opinion in Genetics & Development·Judith Campisi
Nov 27, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jianfei GuoDong-Ming Su
Dec 15, 2010·Current Opinion in Genetics & Development·Christoph A Klein
Jan 25, 2011·Nature Reviews. Cancer·Giulio FranciaRobert S Kerbel
Jun 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hasan KorkayaMax S Wicha
Nov 8, 2011·Annual Review of Medicine·Catherine Alix-PanabièresKlaus Pantel
Feb 19, 2013·Oncogene·A RufiniG Melino
Jun 4, 2013·Nature Cell Biology·Cyrus M GhajarMina J Bissell
Oct 23, 2013·Cancer Research·Rebecca MarlowGabriela Dontu
Apr 24, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kenji YumotoYusuke Shiozawa
Mar 3, 2015·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Andrea PiccioliBarbara Rossi
Jun 2, 2015·BoneKEy Reports·Yusuke ShiozawaRussell S Taichman
Nov 26, 2015·Current Pharmaceutical Design·Morteza Ghandadi, Amirhossein Sahebkar
Dec 17, 2015·Nature Communications·Tackhoon KimDae-Sik Lim
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Neeraj KumariAnant Narayan Bhatt
Oct 27, 2016·International Journal of Molecular Sciences·Casina KanPhilippe Clézardin
Nov 5, 2016·Frontiers in Bioscience (Landmark Edition)·Roland WunderlichUdo S Gaipl
Apr 30, 2017·Frontiers in Immunology·Irene Calvo-AsensioRhodri Ceredig
Nov 9, 2017·PLoS Biology·Jiyoung OhDong-Ming Su
Nov 17, 2017·Blood·Hui-Ling Ou, Björn Schumacher
Nov 18, 2017·Cell Death and Differentiation·Brandon J AubreyAndreas Strasser
Jan 1, 2018·Cell Death and Differentiation·Brandon J AubreyAndreas Strasser

❮ Previous
Next ❯

Citations

Jan 29, 2020·Immunity & Ageing : I & a·Rachel ThomasDong-Ming Su
Sep 10, 2020·Frontiers in Immunology·Sinéad Kinsella, Jarrod A Dudakov
Apr 20, 2021·Cancer Metastasis Reviews·Hendrik Hld VandyckVéronique Winnepenninckx

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
David PáezHeinz-Josef Lenz
© 2022 Meta ULC. All rights reserved