Atrophy of individual thigh muscles measured by MRI in older adults with knee osteoarthritis: A cross-sectional study

Annals of Physical and Rehabilitation Medicine
Koun YamauchiTakayuki Kato

Abstract

The characteristics of thigh-muscle cross-sectional area (CSA) in older adults with knee osteoarthritis (KOA) remain controversial. This study aimed to evaluate atrophy of individual thigh muscles in older adults with KOA and to determine which muscle CSA should be measured to detect KOA-related muscle atrophy of the thigh. In older adults, individual thigh-muscle CSA measured by 1.5 Tesla MRI was analyzed at 5% intervals of the femoral length (FL) around the mid-thigh between the proximal 25% of the FL and the distal 25%. Participants with KOA grade≤1 and grade≥2 were compared for ratios of quadriceps muscle (QM) CSA to total thigh, individual QM CSA to QM, and individual hamstring (HAM) CSA to HAM at 5% intervals. We included 40 older adults [20 males; mean (SD) age 73.3 (4.7) years; 20 with KOA grade≤1 and 20 with KOA grade≥2]. The ratio of vastus medialis (VM) CSA to QM from the proximal 25% to distal 15% and the ratio of semi-membranosus (SM) CSA to HAM at the distal 10% to 25% were significantly lower with KOA grade≥2 than grade≤1; the effect sizes were 0.34 to 0.67 for VM and 0.40 to 0.60 for SM. The effect sizes were greatest for the ratios of VM CSA to QM at the mid-thigh with 5% intervals and the ratio of SM CSA to HA...Continue Reading

Citations

Dec 11, 2019·International Journal of Environmental Research and Public Health·Jae-Ho YangEunwook Chang
Jul 17, 2021·Skeletal Radiology·Wilfred ManzanoRobert D Boutin

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