Atrophy of the thymic cortex in mice with granulomatous schistosomiasis mansoni.

Infection and Immunity
S R Wellhausen, D L Boros

Abstract

Thymic histopathology and granulomatous hypersensitivity were examined in CBA/J mice infected with varying numbers of Schistosoma mansoni worms. At the acute phase (8 weeks) of infection, the thymi of infected mice showed depletion of cortical lymphocytes that resulted in loss of distinction in the corticomedullary region. The degree of cortical depletion correlated directly with the intensity of infection, as assessed by total egg burden of the liver. Adrenalectomy of heavily infected mice 5 to 6 weeks after infection did not alter the course of cortical lymphocyte depletion. Thymus mass was diminished by as much as 80% in heavily infected mice. However, the thymi of lightly infected mice which survived 20 weeks of infection did not differ in histology or total tissue mass from age-matched uninfected controls. Adult thymectomy at 3 weeks of infection did not abrogate the spontaneous modulation (diminution) of granuloma formation in 20-week infected mice, although spleen cells from these mice failed to adoptively transfer suppression. Heavily infected mice which did not survive beyond the acute phase (8 to 9 weeks) of infection displayed a diminished granulomatous response that was partially restored by thymectomy carried out a...Continue Reading

References

Mar 1, 1976·The Journal of Experimental Medicine·D G Colley
Mar 1, 1980·The Journal of Experimental Medicine·Y BorelC L Reinisch
May 1, 1981·Infection and Immunity·M KawabataT Kobayakawa
Oct 1, 1952·Physiological Reviews·T F DOUGHERTY
Feb 28, 1964·Annals of the New York Academy of Sciences·T F DOUGHERTYD L BERLINER

❮ Previous
Next ❯

Citations

Apr 21, 2012·Journal of Parasitology Research·Juliana de MeisWilson Savino
Dec 1, 1983·Infection and Immunity·L B SchookJ E Niederhuber
Jun 12, 2021·Frontiers in Immunology·Mingli LuoXi Sun
Dec 13, 2003·Microbes and Infection·Marcio Mantuano-BarradasPedro M Persechini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.