PMID: 8441735Jan 1, 1993Paper

Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride

Pharmacology & Toxicology
F Worek, L Szinicz

Abstract

The oxime HI 6 is considered to be effective in soman poisoning and less effective in tabun poisoning. Recently, HLö 7 was shown to reactivate acetylcholinesterase (AChE) inhibited by soman and tabun. Therefore, the efficacy of HLö 7 and HI 6 was compared in soman poisoned guinea-pigs. Female Pirbright-white guinea-pigs were anaesthetized with urethane (1.8 g/kg) and the a. carotis, v. jugularis and trachea were cannulated. After base line measurements soman 0.08 mg/kg (= 5 x LD50) or 0.16 mg/kg (= 10 x LD50) was injected intravenously, 2 min. later the antidotes were applied intravenously: HLö 7 0.03 or 0.1 mmol/kg, HI 6 0.03 or 0.1 mmol/kg, atropine 10 mg/kg, or a combination of atropine and an oxime. Respiratory and circulatory parameters were recorded for 60 min. or until the death of the animal. The injection of 5 x LD50 soman resulted in a rapid respiratory arrest followed by circulatory failure in the soman and soman plus oxime groups (survival time about 7 min). Atropine restored the circulatory parameters to base line but was unable to provide a sufficient respiratory function (survival time 26 min.). The combination therapy with atropine plus HLö 7 or HI 6 improved the respiration sufficiently, restored the circulatio...Continue Reading

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Citations

Apr 15, 2003·Toxicology and Applied Pharmacology·Tsung-Ming ShihJohn H McDonough
Oct 4, 2008·Best Practice & Research. Clinical Anaesthesiology·Sara Dichtwald, Avi A Weinbroum
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Trond MyhrerPål Aas
Aug 1, 1995·Human & Experimental Toxicology·F WorekL Szinicz
Oct 3, 2002·Anesthesiology·Ron Ben AbrahamUNKNOWN Department of Anesthesiology and Critical Care Medicine, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicin
Apr 23, 2005·British Medical Bulletin·Avi A Weinbroum
Sep 16, 2003·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Ron Ben Abraham, Avi A Weinbroum

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