PMID: 7336965Jul 1, 1981Paper

Atropine in mouse brain and plasma quantified by mass fragmentography

Acta Pharmacologica Et Toxicologica
L PalmérJ Hermansson

Abstract

A gas chromatography - mass spectrometric method has been developed for the assay of atropine in blood and brain tissue samples of mice. The method is based on the use of deuterium labelled atropine as internal standard and has a sensitivity allowing analyses of small brain structures, e.g. striatum and hippocampus. The method has been used to study the distribution and disposition of atropine in blood and brain of mice. The data obtained in blood can best be fitted by a two compartment open model with the elimination half-life of about 100 min., which was similar to that in brain. The concentration in brain structures with different cholinergic neuronal density was about the same.

References

Jul 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·B KarlénB Holmstedt
Nov 1, 1974·Pharmacology, Biochemistry, and Behavior·S D HarrisonR P Maickel
Aug 1, 1973·Journal of Pharmaceutical Sciences·R S SantoroD E Guttman
Sep 1, 1973·Neuropharmacology·A WitterG K Terpstra
Jan 1, 1950·Acta Pharmacologica Et Toxicologica·M TØNNESEN

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Citations

Dec 1, 1983·Anaesthesia·G L OlssonB M Pettersson
Apr 1, 1988·Archives of Toxicology·K SchoeneM Krügel
Feb 1, 1988·Acta Anaesthesiologica Scandinavica·J Kanto, U Klotz
Nov 1, 1995·Biopharmaceutics & Drug Disposition·A G NybergS A Persson
Apr 22, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melinda Wang, Fred Sanford Gorelick
May 10, 1985·Journal of Chromatography·N Kucharczyk, F H Segelman

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