PMID: 3745060Aug 1, 1986Paper

Atropine: no effect on exercise muscle hyperemia in conscious rats

Journal of Applied Physiology
R B Armstrong, M H Laughlin

Abstract

The purpose of this study was to test the hypothesis that muscarinic cholinergic receptors are involved in the initial vasodilation in red muscle vascular beds of conscious rats performing slow locomotory exercise. Atropine sulfate (1 mg/kg, ia) was administered to one group of rats in which distribution of cardiac output was estimated with radiolabeled microspheres immediately before exercise while the animals were standing on the treadmill and at 30 s and 5 min of treadmill walking at 15 m/min. Blood flows within and among muscles in the atropine-treated animals were compared with flows in control rats that were given a sham injection of an equal volume of physiological saline. Heart rates were elevated above those of control animals in the atropinized rats during preexercise (+17%) and at 30 s of exercise (+15%). However, distributions and magnitudes of blood flows in nonmuscular tissues and within and among skeletal muscles were the same (P greater than 0.05) in atropinized and control rats during preexercise and at both exercise times, indicating that atropine had no effect on the distribution of cardiac output in the rats. It is concluded that muscarinic cholinergic receptors do not play a significant role in elevating mu...Continue Reading

Citations

Nov 6, 1998·Journal of Applied Physiology·J B BuckwalterP S Clifford
Apr 12, 2000·Acta Physiologica Scandinavica·M J Joyner, J R Halliwill
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S A WunschM D Delp
Jan 8, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erika B Westcott, Steven S Segal
Dec 31, 1997·The American Journal of Physiology·J K ShoemakerM J Joyner
Apr 4, 1998·Medicine and Science in Sports and Exercise·M D Delp
Feb 26, 1998·Journal of Applied Physiology·C K DykeM J Joyner
Jul 23, 1999·Medicine and Science in Sports and Exercise·M D Delp
Jul 23, 1999·Medicine and Science in Sports and Exercise·J K Shoemaker, R L Hughson
May 13, 1998·Acta Physiologica Scandinavica·M D Delp, M H Laughlin
Jul 13, 2004·Journal of Applied Physiology·Michael E Tschakovsky, Don D Sheriff
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D W WrayX Shi
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·M Harold LaughlinJames R Turk
Nov 24, 1999·Journal of Applied Physiology·J S NaikP S Clifford
Nov 24, 1999·The American Journal of Physiology·J B Buckwalter, P S Clifford
Feb 14, 1998·Journal of Applied Physiology·J B BuckwalterP S Clifford
Aug 16, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jurgen W G E VanTeeffelen, Steven S Segal
May 15, 2012·Journal of Applied Physiology·J Kevin Shoemaker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.