ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators

ACS Macro Letters
Hua WeiSuzie H Pun

Abstract

Polymers with advanced architectures can now be readily and reproducibly synthesized using controlled living polymerization. These materials are attractive as potential drug carriers due to their tunable size, versatile methods of drug incorporation and release, and ease of functionalization with targeting ligands. In this work, we report the design and development of macrocyclic brush, or "sunflower," polymers, synthesized by controlled radical polymerization of hydrophilic "petals" from a cyclic multimacroinitiator "core." These nanostructures can be synthesized with low polydispersity and controlled sizes depending on polymerization time. We further demonstrate that folate-functionalized sunflower polymers facilitate receptor-mediated uptake into cancer cells. These materials therefore show potential as drug carriers for anti-cancer therapies.

References

Mar 30, 2006·Journal of the American Chemical Society·Boyd A Laurent, Scott M Grayson
Mar 5, 2009·Journal of the American Chemical Society·Norased NasongklaFrancis C Szoka
May 26, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bo ChenFrancis C Szoka
Jun 17, 2009·Journal of the American Chemical Society·Sang-Min LeeSonBinh T Nguyen
Dec 15, 2010·Journal of the American Chemical Society·Jeremiah A JohnsonRobert H Grubbs
Oct 15, 2013·Macromolecular Rapid Communications·Pengcheng Yang, Steven P Armes
Jan 7, 2014·The Journal of Physical Chemistry. B·Lixin LiuSteven W Rick
Apr 25, 2014·Journal of the American Chemical Society·Krzysztof Matyjaszewski, Nicolay V Tsarevsky

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Citations

Nov 26, 2015·Biomacromolecules·Christine E WangSuzie H Pun
Sep 8, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Christine E WangAnthony J Convertine
Jul 1, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·James Iocozzia, Zhiqun Lin
Oct 29, 2018·Advanced Healthcare Materials·Daniel C LeeSuzie H Pun
Oct 30, 2020·Biomaterials·Bianka GolbaBruno G De Geest
Apr 22, 2020·Molecular Pharmaceutics·Yun Hao FengXin Dong Guo

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