PMID: 9632617Jun 25, 1998Paper

Attachment of Cryptosporidium parvum sporozoites to human intestinal epithelial cells

Infection and Immunity
Angela JoeH Ward

Abstract

An enzyme-linked immunosorbent assay-based attachment model using the human intestinal cell line Caco-2A was developed to study attachment of Cryptosporidium parvum sporozoites in vitro and to assess potential inhibitors of sporozoite binding. In this system, attachment was related to sporozoite dose, incubation time, and host cell differentiation status. Polyclonal antibodies to C. parvum as well as glycoprotein inhibitors of a sporozoite lectin reduced attachment. This model will be a valuable tool in elucidating specific molecules and mechanisms involved in sporozoite-host cell attachment.

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Citations

Feb 26, 2000·Infection and Immunity·D F McColeM F Kagnoff
Jun 6, 2006·Applied and Environmental Microbiology·Nihal T GodiwalaBrett A Leav
Oct 2, 2007·The Journal of Biological Chemistry·Najma BhatHonorine D Ward
Mar 23, 2012·PloS One·Mary J MauzyMark S Rutherford
Apr 1, 2014·Parasitology·Matthias Lendner, Arwid Daugschies
Nov 26, 2004·The Journal of Parasitology·Julie K JohnsonMark S Kuhlenschmidt
Jan 31, 2002·World Journal of Gastroenterology : WJG·Xian-Ming Chen, Nicholas F LaRusso
Jun 30, 2019·Applied and Environmental Microbiology·Tooba SarkhoshSabrina S Jedlicka
Jan 21, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·A R IshaqF Noor
Feb 20, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·A R IshaqF Noor
Oct 24, 2006·Biotechnology Advances·Jeanine I Boulter-BitzerJack T Trevors

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