PMID: 15352499Sep 9, 2004Paper

Attachment of DNA to the carbon fiber microelectrode via gold nanoparticles for simultaneous determination of dopamine and serotonin

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Liping LuXiangqin Lin

Abstract

A novel biochemical sensor was fabricated on a carbon fiber microelectrode, which consisted of an inner layer of electrodeposited gold nanoparticles, as a nano-array electrode, and an outer layer of electrodeposited calf thymus ds-DNA at +1.5 V vs. SCE. This modified electrode was characterized by X-ray photoelectron spectroscopy, scanning electron microscope, atomic force microscopy, cyclic voltammetry and differential pulse voltammetry (DPV). It was found that this electrochemical sensor exhibits a strong catalytic activity toward the oxidation of dopamine (DA), serotonin (5-HT) and ascorbic acid (AA), as a result of resolving the anodic voltammetric peaks of DA, 5-HT and AA into three well-defined peaks. Simutaneous DPV determination of DA and 5-HT can be achieved in the presence of 2000-fold AA. The modified electrode shows good sensitivity, selectivity and stability.

References

Jan 18, 1967·Journal of the American Chemical Society·M D HawleyR N Adams
Jan 5, 2001·Analytical Chemistry·B D BathR M Wightman
Feb 24, 2001·Fresenius' Journal of Analytical Chemistry·M MasciniG Marrazza
Aug 9, 2001·Journal of the American Chemical Society·Y CaoC A Mirkin
Aug 24, 2002·Analytical and Bioanalytical Chemistry·Ana Maria Oliveira-Brett, Luís Antônio da Silva
Aug 31, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xiayan WangXiangqin Lin
Apr 8, 2004·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Liping Lu, Xiangqin Lin
Oct 31, 2008·Talanta·A M Oliveira-BrettJ A P Piedade

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