PMID: 9438881Aug 1, 1997Paper

Attachment site of grafted SCN influences precision of restored circadian rhythm

Journal of Biological Rhythms
J LesauterR Silver

Abstract

Fetal hypothalamic grafts containing the suprachiasmatic nucleus (SCN) restore circadian locomotor rhythmicity when implanted into the third ventricle of SCN-lesioned hamsters. However, the quality of restored rhythms is variable, and the locomotor rhythms of grafted animals are generally less robust than those of intact animals. The present study explored whether anatomical features of the graft predict the quality of the recovered rhythm and whether such information might provide insight as to the target of the signal from the SCN that controls locomotor rhythmicity. The following graft parameters were assessed: distance between the attachment site of the graft and potential targets for the output signal from the SCN, number and overall size of SCN clusters, the size of the cluster closest to the SCN lesion site, and extent of vasoactive intestinal polypeptide (VIP) and vasopressin-associated neurophysin (NP) positive fiber outgrowth from the graft. The restored circadian activity rhythm was assessed by quantifying the precision of activity onset and the amount, period, and robustness of rhythmicity. The results indicate a significant positive correlation between the precision of activity onset and the proximity of the closes...Continue Reading

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Citations

Sep 1, 2000·Brain Research. Brain Research Reviews·K E van EsseveldtG J Boer
Feb 17, 2010·Cerebrospinal Fluid Research·Jan G Veening, Henk P Barendregt
May 28, 2014·Nature Reviews. Endocrinology·Karen L GambleMartin E Young
Jan 24, 2006·Nature Neuroscience·Sebastian Kraves, Charles J Weitz
Oct 27, 1998·Chronobiology International·J LeSauter, R Silver
Jun 19, 2012·The European Journal of Neuroscience·Matthew P ButlerRae Silver
Dec 13, 2005·Brain Research Reviews·L P Morin, C N Allen
Nov 5, 2014·Journal of Pineal Research·Jerry Vriend, Russel J Reiter
Jun 28, 2003·Journal of Biological Rhythms·Ueli SchiblerSteven A Brown
Dec 19, 2018·Nature Reviews. Neuroscience·Carolina Magdalen Greco, Paolo Sassone-Corsi
Feb 1, 2021·Experimental Gerontology·Fabian-Xosé FernandezDavid C Negelspach

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