PMID: 6110037Feb 21, 1981Paper

Attack rate of poststreptococcal nephritis in families. A prospective study

Lancet
B Rodríguez-IturbeR García

Abstract

Twenty-two families comprising 141 first-degree relatives (42 parents and 99 siblings) were studied prospectively after the appearance in the family of an index case with acute poststreptococcal glomerulonephritis (APSGN). There was no epidemic when the studies were conducted. Families were observed weekly for 4-6 weeks after the appearance of the index case, and at least every 6 months thereafter for 1-3 years. At each examination all members of the family gave a history and had a physical examination, urine analysis, and appropriate cultures; antistreptococcal antibody titres and serum C3 were determined. 33 parents and 95 siblings showed changes in antistreptococcal antibody titres suggestive of infection during or shortly before the period of weekly observation. Group A streptococci of various M and T types were isolated from 17 individuals in 14 families. 25 cases of clincal APSGN (including 22 index cases) and 12 cases of asymptomatic APSGN were detected. The results indicate that within families the streptococci responsible for nonepidemic APSGN are very infectious. The subclinical/clinical disease ratio (excluding index cases) was 4.0. The high attack rate (37.8%) in 77 sibling contacts at risk may indictae that suscept...Continue Reading

References

Jun 1, 1968·The Journal of Pediatrics·E V PotterS Abidh
Sep 1, 1969·The Journal of Clinical Investigation·B F AnthonyS S Chapman

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Citations

Aug 15, 1982·Experientia·B Rodríguez-IturbeZ Layrisse
Jul 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T Matthew EisonRobert J Wyatt
Mar 26, 2003·Journal of Paediatrics and Child Health·V Tasic, M Polenakovic
Jan 11, 2013·Kidney International·Samih H NasrVivette D D'Agati
Mar 8, 2007·Kidney International·B Rodríguez-Iturbe, S Batsford
Aug 11, 2018·Clinical Pediatrics·Rebecca J Sainato, Martin E Weisse
Apr 23, 2009·Nature Reviews. Nephrology·Talerngsak KanjanabuchSomchai Eiam-Ong
Mar 30, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Fernando C FervenzaAnthony J Bleyer
Jun 11, 2020·Pediatric Annals·Dunya Mohammad, Rossana Baracco
Mar 28, 2019·The American Journal of Tropical Medicine and Hygiene·Kate A WorthingMark R Davies
Aug 11, 2019·Nature Reviews. Nephrology·Anjali A SatoskarTibor Nadasdy
Oct 9, 2020·International Reviews of Immunology·Jesús Mosquera, Adriana Pedreañez
Feb 4, 2021·Journal of the American Society of Nephrology : JASN·Bernardo Rodriguez-Iturbe
Dec 8, 2009·Pediatric Clinics of North America·Gurmeet R Singh
Jan 1, 1984·Kidney International·B Rodríguez-Iturbe

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