Oct 14, 2014

Attained height, sex, and risk of cancer at different anatomic sites in the NIH-AARP diet and health study

Cancer Causes & Control : CCC
Geoffrey C KabatThomas E Rohan

Abstract

To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women. The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the association of height with cancer risk. After adjustment for covariates, height was positively associated with increased risk of all cancers combined in both men [HR10 cm increase = 1.05 (95 % CI 1.04-1.06)] and women [HR10 cm increase = 1.08 (95 % CI 1.06-1.10)]. Several sites common to men and women showed significant positive associations with height: colon, rectum, kidney, melanoma, and non-Hodgkin's lymphoma. For other shared sites, the association differed by sex. For still other sites, there was no clear association with height. Positive associations were also observed with cancers of the breast, endometrium, and prostate. Different patterns were observed in the height-cancer association by sex. S...Continue Reading

  • References29
  • Citations14

References

  • References29
  • Citations14

Citations

Mentioned in this Paper

Lymphoma, Non-Hodgkin
Diet
Endometrium
Neoplasms
Incidence Studies
Anatomic Site
Melanoma vaccine
Carcinoma in Situ of Endometrium
Malignant Neoplasms
Cox Proportional Hazards Models

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