Attempted experimental infection of domestic goats with Ehrlichia chaffeensis

Vector Borne and Zoonotic Diseases
Vivien G DuganSusan E Little

Abstract

Although white-tailed deer (WTD; Odocoileus virginianus ) are considered the primary natural reservoir host for Ehrlichia chaffeensis, the causative agent of human monocytotropic ehrlichiosis, the potential role of other vertebrates as reservoir hosts has not been fully explored. Because domestic goats are naturally infected in areas where E. chaffeensis is endemic in deer, we evaluated the susceptibility of domestic goats to experimental infection with E. chaffeensis. A total of 12 goats were inoculated with E. chaffeensis (15B-WTD-GA or Ark strain)-infected DH82 cells by one of three routes: intravenously, subcutaneously, or intradermally. White-tailed deer simultaneously inoculated with the same dose, route, and inoculum served as positive controls; additional goats and WTD were included as negative controls. Evidence of E. chaffeensis infection was evaluated in all animals by indirect fluorescent antibody assay, PCR, and cell culture isolation techniques. All goats exposed to E. chaffeensis seroconverted by 14 days post-infection (DPI), and E. chaffeensis was isolated from one goat on 3 DPI; however, molecular or cell culture evidence of active infection was not detected in goats later than 3 DPI. White-tailed deer exhibite...Continue Reading

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Citations

Jul 14, 2005·Vector Borne and Zoonotic Diseases·Vivien G DuganWilliam R Davidson
Jun 27, 2006·Vector Borne and Zoonotic Diseases·Andrea S Varela-StokesSusan E Little
Mar 1, 2005·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Michael J YabsleyWilliam R Davidson
Jan 2, 2013·Ticks and Tick-borne Diseases·Cynthia M TateMichael J Yabsley
Dec 5, 2008·Veterinary Parasitology·Jerome Goddard, Andrea S Varela-Stokes
Mar 11, 2008·Veterinary Microbiology·Amanda D LoftisJ Paul Spurlock
Nov 24, 2007·Journal of Medical Microbiology·Jose R C Delos SantosRoger W Stich

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