PMID: 6978359Mar 1, 1982Paper

Attempts to establish infections with Strongyloides stercoralis in mice and other laboratory animals

Journal of Helminthology
H J Dawkins, D I Grove

Abstract

Infection of a dog with Strongyloides stercoralis filariform larvae resulted in a persistent infection. Patent infections were not seen in rabbits, guinea-pigs, rats and 11 inbred strains and one outbred strain of mice. Manipulation of factors known to influence S. ratti infections in mice, such as age and sex of the host and the route of larval presentation, did not facilitate the appearance of rhabditiform larvae in the stools. Administration of immunosuppressive doses of corticosterioids to rabbits, guniea-pigs and C57Bl/6 mice did not permit complete development. Similarly, th course of infection was not altered in T cell-deficient hypothymic (nu/nu) mice. The fate of filariform larvae applied to the skin of mice was ascertained; filariform larvae were observed to migrate from the skin via the lungs to the muscles within several days of infection. Although S. Stercoralis does not develop to maturity in the small intestine of mice, this system does allow in vivo studies of the actions of anthelmintics against filariform larvae as well as a number of aspects of the immune response to this parasite.

References

Jan 1, 1978·Advances in Parasitology·D Wakelin
Feb 1, 1981·International Journal for Parasitology·H J Dawkins, D I Grove

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Citations

Jan 1, 1982·Zeitschrift Für Parasitenkunde·H J Dawkins, D I Grove
Jun 1, 2006·Clinical and Molecular Allergy : CMA·Raja S VadlamudiGuha Krishnaswamy
Nov 22, 2011·Immunologic Research·Sandra Bonne-AnnéeDavid Abraham
Jul 5, 2011·Experimental Parasitology·Wiebke HartmannMinka Breloer
Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I Grove, C Northern
Feb 26, 2016·Parasitology·Minka Breloer, David Abraham
Mar 15, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Teresa Cristina Goulart Oliveira-SequeiraJulio Lopes Sequeira
Feb 18, 2017·Journal of Parasitology Research·Tiago MendesSilmara Marques Allegretti
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C C WangD Abraham
Mar 5, 2002·Parasite Immunology·De'broski R HerbertDavid Abraham
Dec 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·John B PattonDavid Abraham
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D R HerbertD Abraham
Feb 1, 2020·Veterinary Parasitology·Fernanda S CostaDeborah Negrão-Corrêa

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