PMID: 3319358Sep 1, 1987Paper

Attempts towards a serological diagnosis of ankylosing spondylitis

Clinical Rheumatology
H J LakomekH L Krüskemper

Abstract

Polytene chromosomes of salivary glands as well as nuclear proteins from Kc-cells of Drosophila melanogaster have been used as substrate to identify and evaluate the diagnostic value of crossreacting antibodies present in sera of AS patients. The diagnostic significance of the recently described anti-93D antibody (Lakomek et al., 1984) was confirmed by screening sera of patients with definite or suspected AS using cytoimmunofluorescence on the polytene chromosomes. In addition, four new antibodies could be identified in AS sera by immunoblotting. Simultaneous detection of these antibodies supports the diagnosis of AS and is most useful in diagnosis of early stages of this disease.

References

Jun 1, 1979·Cell·M Ashburner, J J Bonner
Oct 23, 1975·The New England Journal of Medicine·A Calin, J F Fries
Sep 1, 1976·Arthritis and Rheumatism·R W Lightfoot, G R Hughes
Apr 28, 1973·Lancet·D A BrewertonR D Sturrock
Jul 1, 1973·Annals of the Rheumatic Diseases·J M Moll, V Wright
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
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Sep 1, 1984·Arthritis and Rheumatism·H J LakomekH L Krüskemper
Sep 1, 1961·Annals of the Rheumatic Diseases·J de BLECOURT de BLECOURT-MEINDERSMA
Dec 5, 1964·Nature·P I TERASAKI, J D MCCLELLAND

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Citations

Nov 1, 1991·Annals of the Rheumatic Diseases·H J LakomekM Schwochau
Sep 23, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Olivier Meyer
Oct 5, 2007·Current Rheumatology Reports·In-Ho SongMartin Rudwaleit
Oct 1, 1991·Annals of Medicine·J M MartinB Robinson
Jul 31, 2013·Annals of the Rheumatic Diseases·Florence W L TsuiRobert D Inman

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