Attention and Working Memory in Adolescents with Autism Spectrum Disorder: A Functional MRI Study

Child Psychiatry and Human Development
Jukka S RahkoVesa J Kiviniemi

Abstract

The present study examined attention and memory load-dependent differences in the brain activation and deactivation patterns between adolescents with autism spectrum disorders (ASDs) and typically developing (TD) controls using functional magnetic resonance imaging. Attentional (0-back) and working memory (WM; 2-back) processing and load differences (0 vs. 2-back) were analysed. WM-related areas activated and default mode network deactivated normally in ASDs as a function of task load. ASDs performed the attentional 0-back task similarly to TD controls but showed increased deactivation in cerebellum and right temporal cortical areas and weaker activation in other cerebellar areas. Increasing task load resulted in multiple responses in ASDs compared to TD and in inadequate modulation of brain activity in right insula, primary somatosensory, motor and auditory cortices. The changes during attentional task may reflect compensatory mechanisms enabling normal behavioral performance. The inadequate memory load-dependent modulation of activity suggests diminished compensatory potential in ASD.

References

Nov 1, 1991·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S OzonoffS J Rogers
Jan 1, 1991·Computer Methods and Programs in Biomedicine·B A Tanner
Jun 1, 1990·Journal of Autism and Developmental Disorders·J M Rumsey, S D Hamburger
Mar 1, 1985·Journal of Autism and Developmental Disorders·J M Rumsey
Aug 1, 1995·Journal of Autism and Developmental Disorders·P C DiLavoreM Rutter
Jan 28, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·D F ConnorR J Harrison
Sep 9, 1999·Journal of Autism and Developmental Disorders·B KadesjöB Hagberg
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Jan 22, 2002·Biological Psychiatry·James V HaxbyM Ida Gobbini
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Sep 28, 2002·Development and Psychopathology·Geraldine DawsonTodd Richards
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Mar 18, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert T SchultzPawel Skudlarski
Jan 20, 2004·Neuropsychologia·M-J CaronS Chouinard
Mar 31, 2004·NeuroImage·Mark W WoolrichStephen M Smith
Jul 28, 2004·NeuroImage·Tor D WagerSusan Reading
Dec 21, 2004·Neurobiology of Learning and Memory·E T AronenS Carlson
Aug 24, 2005·The European Journal of Neuroscience·E Jansson-VerkasaloP Korpilahti
Nov 23, 2005·Neuron·Brian T Miller, Mark D'Esposito
Dec 6, 2005·Neuroscience·E AwhS-H Oh
Feb 2, 2006·Journal of Autism and Developmental Disorders·Francesca Happé, Uta Frith
Apr 15, 2006·Autism : the International Journal of Research and Practice·Miriam LissMarcel Kinsbourne
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel P KennedyEric Courchesne
May 23, 2006·Trends in Cognitive Sciences·Marlene BehrmannKate Humphreys
Jun 24, 2006·Neuropsychology Review·Julie A Alvarez, Eugene Emory
Jan 16, 2007·NeuroImage·Robert G ShulmanFahmeed Hyder
Apr 24, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Marja-Leena MattilaIrma Moilanen
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David E J Linden

❮ Previous
Next ❯

Citations

Mar 30, 2018·Autism : the International Journal of Research and Practice·Vanessa M VoganMargot J Taylor
Sep 22, 2020·Brain Communications·Samantha P AudrainMargot J Taylor
Jun 3, 2018·Journal of Neurodevelopmental Disorders·Vanessa M VoganMargot J Taylor
Oct 10, 2020·Frontiers in Psychiatry·Veronica YukMargot J Taylor
Nov 19, 2020·Autism Research : Official Journal of the International Society for Autism Research·Aija KotilaVille Raatikainen
May 25, 2021·International Journal of Circumpolar Health·Aija KotilaSoile Loukusa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.