Attention deficits in tuberous sclerosis complex (TSC): rethinking the pathways to the endstate

Journal of Intellectual Disability Research : JIDR
P J de Vries, P Watson

Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder associated with a range of neurocognitive manifestations, including neuropsychological attention deficits most notably in dual tasking/divided attention. These dual-task deficits have so far been interpreted as evidence of a vulnerable 'cognitive module' in TSC. Here, we suggest that this interpretation represents an 'adult neuropsychological' perspective, and argue that a developmental approach would be more appropriate to examine attention deficits in TSC. We examined the pathway to 'endstate' dual-task deficits in twenty 6-16 year olds with TSC utilising the Test of Everyday Attention for Children (TEA-Ch). We predicted that the pattern of attentional deficits in TSC would support a 'conditional' model where the establishment of a later-maturing skill was dependent on the functional maturation of an earlier expected skill. Attentional profiles showed statistical support for a conditional model. Only one child showed a deterministic pattern while one showed a hybrid pattern, attributed to the admixture of a surgically acquired lesion and a neurodevelopmental disorder. This preliminary study suggests that the developmental cascade in TSC may be arrested at various stages o...Continue Reading

References

Apr 1, 1987·Journal of Experimental Child Psychology·B E SheppL L Kolbet
May 1, 1994·Annals of Human Genetics·S PoveyE B Robson
Jul 1, 1994·Biological Psychiatry·I L Cohen
Feb 1, 1997·The British Journal of Surgery·R L Dunn, D L Harris
Oct 23, 1997·The Journal of Comparative Neurology·P R Huttenlocher, A S Dabholkar
Nov 5, 1997·Trends in Neurosciences·J M Fuster
Jan 14, 1998·Biological Psychiatry·L Gustafsson
Jan 9, 1999·Journal of Child Neurology·E S RoachH Northrup
May 11, 1999·Trends in Cognitive Sciences·S R Quartz
Jul 4, 2001·Nature Reviews. Neuroscience·M H Johnson
Jan 25, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·T ManlyI H Robertson
Sep 28, 2002·Development and Psychopathology·Mark H JohnsonAnnette Karmiloff-Smith
May 1, 1956·British Journal of Psychology·J C RAVEN
Nov 6, 2003·The Behavioral and Brain Sciences·Michael Thomas, Annette Karmiloff-Smith
Dec 3, 2003·Trends in Cognitive Sciences·Usha Goswami
Nov 26, 2004·Journal of Child Neurology·Penny Prather, Petrus J de Vries
Jun 28, 2005·European Child & Adolescent Psychiatry·Petrus de VriesUNKNOWN TSC Behaviour Consensus Panel
Jul 14, 2006·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Jennifer BettsVicki Anderson
Sep 29, 2006·The New England Journal of Medicine·Peter B CrinoElizabeth Petri Henske
Oct 25, 2006·Neural Networks : the Official Journal of the International Neural Network Society·Michael I PosnerYiYuan Tang
Jan 5, 2007·The New England Journal of Medicine·Petrus J de Vries, Penny A Prather
Oct 1, 1998·Trends in Cognitive Sciences·A Karmiloff-Smith

❮ Previous
Next ❯

Citations

Oct 24, 2007·Neuropsychology Review·Chris E Morrison, Luba Nakhutina
Oct 7, 2009·Journal of Child Neurology·Elisa D'AgatiPaolo Curatolo
Aug 18, 2018·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Petrus J de VriesPaolo Curatolo
Sep 8, 2020·Orphanet Journal of Rare Diseases·Francesca CerviAglaia Vignoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.