Attention Stabilizes Representations in the Human Hippocampus

Cerebral Cortex
Mariam Aly, Nicholas B Turk-Browne

Abstract

Attention and memory are intricately linked, but how attention modulates brain areas that subserve memory, such as the hippocampus, is unknown. We hypothesized that attention may stabilize patterns of activity in human hippocampus, resulting in distinct but reliable activity patterns for different attentional states. To test this prediction, we utilized high-resolution functional magnetic resonance imaging and a novel "art gallery" task. On each trial, participants viewed a room containing a painting, and searched a stream of rooms for a painting from the same artist (art state) or a room with the same layout (room state). Bottom-up stimulation was the same in both tasks, enabling the isolation of neural effects related to top-down attention. Multivariate analyses revealed greater pattern similarity in all hippocampal subfields for trials from the same, compared with different, attentional state. This stability was greater for the room than art state, was unrelated to univariate activity, and, in CA2/CA3/DG, was correlated with behavior. Attention therefore induces representational stability in the human hippocampus, resulting in distinct activity patterns for different attentional states. Modulation of hippocampal representati...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A Fenton, R U Muller
Oct 19, 1999·Nature·K M O'CravenN Kanwisher
Jun 9, 2000·Annual Review of Neuroscience·S Kastner, L G Ungerleider
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Jun 11, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuhei YamaguchiRobert T Knight
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Keith J WorsleyAlan C Evans
Mar 18, 2006·Neuron·Jennifer J SummerfieldAnna C Nobre
May 6, 2006·Neuron·R Alison AdcockJohn D E Gabrieli
May 16, 2006·Trends in Neurosciences·John H R Maunsell, Stefan Treue
Nov 14, 2006·Current Opinion in Neurobiology·Lila Davachi
Dec 5, 2006·Hippocampus·Tom HartleyNeil Burgess
Mar 24, 2007·Current Opinion in Neurobiology·Marvin M Chun, Nicholas B Turk-Browne
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam Johnson, A David Redish
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deborah E Hannula, Charan Ranganath
Oct 30, 2008·Frontiers in Human Neuroscience·Marianne MaertensHarald Möller
Mar 17, 2009·Current Biology : CB·Demis HassabisEleanor A Maguire
Jun 16, 2009·The Journal of Physiology·Isabel A MuzzioEric Kandel
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melina R Uncapher, Michael D Rugg
Jul 7, 2009·Annual Review of Psychology·Marvin M ChunNicholas B Turk-Browne
Sep 8, 2009·Progress in Brain Research·Oliver Hardt, Lynn Nadel
Mar 17, 2010·Current Biology : CB·Martin J ChadwickEleanor A Maguire
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·André A FentonAndrey V Olypher
May 4, 2010·Journal of Cognitive Neuroscience·Nicole M DudukovicAnthony D Wagner
May 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thackery I BrownChantal E Stern
Jun 10, 2011·Hippocampus·Heidi M BonniciEleanor A Maguire
Nov 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mark G StokesAnna Christina Nobre
Jan 26, 2012·Cerebral Cortex·Jackson C LiangAlison R Preston
Apr 25, 2012·Frontiers in Human Neuroscience·Andy C H LeeMorgan D Barense
Jun 19, 2012·Frontiers in Behavioral Neuroscience·Ehren L NewmanMichael E Hasselmo
Jan 22, 2013·Frontiers in Psychology·Cyril R PernetGuillaume A Rousselet
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karen F LaRocqueAnthony D Wagner
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lindsay K Vass, Russell A Epstein
Apr 19, 2013·Nature Reviews. Neuroscience·Charles D Gilbert, Wu Li
Jun 7, 2013·Annals of the New York Academy of Sciences·Tyler Davis, Russell A Poldrack

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Citations

Jan 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Mariam Aly, Nicholas B Turk-Browne
Sep 4, 2015·Hippocampus·Anna C SchapiroMatthew M Botvinick
Jul 26, 2016·Frontiers in Psychology·Manuela Macedonia, Karsten Mueller
Nov 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael L MackAlison R Preston
Mar 30, 2021·Frontiers in Psychology·Mrinmayi Kulkarni, Deborah E Hannula
May 20, 2020·Journal of Cognitive Neuroscience·Nicholas A RuizMariam Aly
Dec 11, 2019·Journal of Cognitive Neuroscience·Peter KokNicholas B Turk-Browne
Sep 14, 2021·Frontiers in Systems Neuroscience·Tae-Hyeong KimMin-Hyeon Park

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