Attentional modulation of thalamic reticular neurons.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Kerry McAlonanRobert H Wurtz

Abstract

The major pathway for visual information reaching cerebral cortex is through the lateral geniculate nucleus (LGN) of the thalamus. Acting on this vital relay is another thalamic nucleus, the thalamic reticular nucleus (TRN). This nucleus receives topographically organized collaterals from both thalamus and cortex and sends similarly organized projections back to thalamus. The inputs to the TRN are excitatory, but the output back to the thalamic relay is inhibitory, providing an ideal organization for modulating visual activity during early processing. This functional architecture led Crick in 1984 to hypothesize that TRN serves to direct a searchlight of attention to different regions of the topographic map; however, despite the substantial influence of this hypothesis, the activity of TRN neurons has never been determined during an attention task. We have determined the nature of the response of visual TRN neurons in awake monkeys, and the modulation of that response as the monkeys shifted attention between visual and auditory stimuli. Visual TRN neurons had a strong (194 spikes/s) and fast (25 ms latency) transient increase of activity to spots of light falling in their receptive fields, as well as high background firing rate...Continue Reading

Citations

Mar 19, 2013·Brain Research Bulletin·Jorge H PazoNoel Almarares
Sep 2, 2011·Visual Neuroscience·Thomas Fitzgibbon, Nick Kikuchi
Dec 15, 2010·Nature Neuroscience·Chen-Chung Lee, John C Middlebrooks
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael E Hasselmo, Martin Sarter
Jul 11, 2007·Cerebral Cortex·William K Page, Charles J Duffy
Dec 7, 2010·Schizophrenia Bulletin·Fabio Ferrarelli, Giulio Tononi
Nov 21, 2007·Journal of Neurologic Physical Therapy : JNPT·Joan M McDowd
Oct 25, 2011·Science·Julie S HaasCarole E Landisman
May 21, 2013·Annual Review of Neuroscience·Richard J KrauzlisAlexandre Zénon
Apr 10, 2007·Annual Review of Neuroscience·Eric I Knudsen
Jan 16, 2009·Journal of Neurophysiology·J Patrick Mayo
Jun 19, 2010·PloS One·Karen Johanne PallesenSynnöve Carlson
Nov 19, 2011·PloS One·Fredrik LindstedtMartin Ingvar
Nov 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vladimir MarlinskiIrina N Beloozerova
Jun 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Gang SunMichael Beierlein
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying-Wan Lam, S Murray Sherman
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan-Gang SunMichael Beierlein
Nov 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane R CrandallCharles L Cox
Jan 19, 2016·Frontiers in Neural Circuits·Zhe ChenMichael M Halassa
Jan 15, 2015·Schizophrenia Research·Samuel M CohenMichael M Halassa
Jul 10, 2012·Brain Research·Julie S Haas, Carole E Landisman
Jan 7, 2016·Frontiers in Neural Circuits·Sébastien BéhuretThierry Bal
Dec 28, 2010·Neuroscience and Biobehavioral Reviews·Karsten RaussGilles Pourtois
Sep 23, 2008·Current Opinion in Neurobiology·Farran Briggs, W Martin Usrey
Aug 5, 2008·Trends in Neurosciences·Andreas BartelsKonstantinos Moutoussis
Aug 24, 2007·Current Opinion in Neurobiology·Jonathan B FritzShihab A Shamma
Nov 20, 2015·Frontiers in Psychology·Farid MasrourEmily Barrett
Oct 9, 2015·Neuron·Timothy J Buschman, Sabine Kastner
Oct 31, 2008·Human Brain Mapping·Charles Chong-Hwa HongJames J Pekar
Dec 7, 2013·The European Journal of Neuroscience·Michael C AveryJeffrey L Krichmar
Dec 20, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Konstantinos MargetisDamianos E Sakas
May 2, 2009·Biochemical Pharmacology·Martin SarterWilliam M Howe
Apr 5, 2016·Cell Calcium·Christina NeyerPhilippe Coulon
Jun 29, 2015·Trends in Neurosciences·Yael GollAmi Citri
Mar 4, 2015·Human Brain Mapping·Jesse J BengsonGeorge R Mangun
Jul 15, 2015·Annual Review of Neuroscience·Judith A HirschLuis M Martinez

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