Attentional processing in C57BL/6J mice exposed to developmental vitamin D deficiency.

PloS One
L H HarmsThomas H J Burne

Abstract

Epidemiological evidence suggests that Developmental Vitamin D (DVD) deficiency is associated with an increased risk of schizophrenia. DVD deficiency in mice is associated with altered behaviour, however there has been no detailed investigation of cognitive behaviours in DVD-deficient mice. The aim of this study was to determine the effect of DVD deficiency on a range of cognitive tasks assessing attentional processing in C57BL/6J mice. DVD deficiency was established by feeding female C57BL/6J mice a vitamin D-deficient diet from four weeks of age. After six weeks on the diet, vitamin D-deficient and control females were mated with vitamin D-normal males and upon birth of the pups, all dams were returned to a diet containing vitamin D. The adult offspring were tested on a range of cognitive behavioural tests, including the five-choice serial reaction task (5C-SRT) and five-choice continuous performance test (5C-CPT), as well as latent inhibition using a fear conditioning paradigm. DVD deficiency was not associated with altered attentional performance on the 5C-SRT. In the 5C-CPT DVD-deficient male mice exhibited an impairment in inhibiting repetitive responses by making more perseverative responses, with no changes in premature...Continue Reading

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Feb 3, 2016·Physiology & Behavior·Natalie J Groves, Thomas H J Burne
Dec 6, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jared W YoungGregory A Light
Jun 7, 2017·Schizophrenia Bulletin·Samuel A BarnesJared W Young
Feb 16, 2017·Frontiers in Behavioral Neuroscience·Karly M TurnerThomas H J Burne
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Jan 28, 2021·Molecular Psychiatry·Xiaoying CuiDarryl W Eyles
Feb 9, 2021·JBMR Plus·Darryl Walter Eyles

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