Attenuated beta rebound to proprioceptive afferent feedback in Parkinson's disease

Scientific Reports
Mikkel C VindingDaniel Lundqvist

Abstract

Motor symptoms are defining traits in the diagnosis of Parkinson's disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8-30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical process...Continue Reading

References

Jun 1, 1990·Brain : a Journal of Neurology·A M BronsteinC Panagi
May 1, 1967·Neurology·M M Hoehn, M D Yahr
May 1, 1995·Electroencephalography and Clinical Neurophysiology·J Kalcher, G Pfurtscheller
Nov 1, 1994·Journal of Neurophysiology·M J Prud'homme, J F Kalaska
Apr 1, 1996·Electroencephalography and Clinical Neurophysiology·G PfurtschellerC Neuper
Sep 20, 1996·Neuroscience Letters·C Neuper, G Pfurtscheller
Jun 1, 1997·Annals of Neurology·M DemirciM Hallett
Feb 5, 1998·Brain Research. Cognitive Brain Research·J XiangR Kakigi
Jul 29, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·G PfurtschellerF Reisecker
Oct 8, 1998·Brain : a Journal of Neurology·S J FellowsM Schwarz
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
Oct 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·P O'SuilleabhainR B Dewey
Oct 3, 2002·Nature Reviews. Neuroscience·Volker Dietz
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Mar 7, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni Abbruzzese, Alfredo Berardelli
Jun 25, 2003·Brain : a Journal of Neurology·Matthias MaschkeJürgen Konczak
Sep 24, 2004·Brain Topography·Samu TauluJuha Simola
Mar 19, 2005·Brain : a Journal of Neurology·Paul SilbersteinPeter Brown
Mar 10, 2006·Experimental Brain Research·Dennis A Nowak, Joachim Hermsdörfer
Apr 21, 2006·The European Journal of Neuroscience·Andrea A KühnPeter Brown
May 11, 2006·Brain : a Journal of Neurology·F Alonso-FrechJ A Obeso
Sep 26, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J L W BosboomE Ch Wolters
Oct 31, 2006·Progress in Brain Research·Riitta Hari
Nov 23, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzNancy LaPelle
Apr 11, 2007·Journal of Neurology·Jürgen KonczakMatthias Maschke
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Feb 7, 2008·IEEE Transactions on Neural Networks·A Hyvärinen
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletPeter J Magill
Jul 10, 2008·PloS One·Jürgen KonczakHoward Poizner
Nov 5, 2008·Journal of Neural Transmission·J L W BosboomH W Berendse
Mar 19, 2009·Psychonomic Bulletin & Review·Jeffrey N RouderGeoffrey Iverson
Jul 14, 2009·Journal of Motor Behavior·Jürgen KonczakMatthias Maschke
Nov 17, 2009·Lancet Neurology·Maria C Rodriguez-OrozJosé A Obeso
Apr 3, 2010·Current Opinion in Neurobiology·Andreas K Engel, Pascal Fries

❮ Previous
Next ❯

Citations

Jun 17, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Viviana BettiMaurizio Corbetta
Sep 22, 2020·Brain Communications·Mikkel C VindingDaniel Lundqvist
Oct 29, 2020·Journal of Neurophysiology·Harri PiitulainenMathieu Bourguignon
Jan 9, 2022·Scientific Reports·Olena V BogdanovaFadila Hadj-Bouziane

❮ Previous
Next ❯

Software Mentioned

Matlab
FieldTrip
Presentation
Python
MNE

Related Concepts

Related Feeds

Researcher Network:CZI Neurodegeneration Challenge

The Neurodegeneration Challenge Network aims to provide funding for and to bring together researchers studying neurodegenerative diseases. Find the latest research from the NDCN grantees here.