Attenuated endothelial function is associated with decreased endothelial progenitor cells and nitric oxide in premenopausal diabetic women

Molecular Medicine Reports
Juan LiuZ Yang

Abstract

Previous studies have demonstrated that the deleterious effect of diabetes mellitus (DM) on the risk of cardiovascular disease also occurs in premenopausal women, in spite of their relatively high estrogen levels; however, the underlying mechanism remains unclear. The present study aimed to investigate the sex‑related differences in circulating endothelial progenitor cells (EPCs) in a relatively young population with type 2 DM (T2DM) and its underlying mechanism. The number and functional activity of circulating EPCs, and vascular endothelial function assessed using flow‑mediated dilation (FMD), were compared in premenopausal women and age‑matched men with or without T2DM. Nitric oxide (NO) in the plasma or NO secreted by EPCs was also measured. The number and activity of circulating EPCs, and NO levels in the plasma or culture medium, were lower in premenopausal women with T2DM compared with those without T2DM. In addition, the number and activity of circulating EPCs and NO levels were decreased in men with T2DM compared with in age‑matched premenopausal women with T2DM. FMD was positively correlated with the number and activity of circulating EPCs, and NO levels. In conclusion, DM in premenopausal women may significantly impa...Continue Reading

References

Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Matthew J Sheetz, George L King
Sep 8, 2004·Trends in Molecular Medicine·Alexandra AicherStefanie Dimmeler
Jan 19, 2005·Hypertension·Alexandra AicherStefanie Dimmeler
Feb 6, 2007·Diabetes Care·Gian Paolo FadiniAngelo Avogaro
Oct 29, 2008·Diabetes Research and Clinical Practice·Angelo AvogaroGianpaolo Fadini
Sep 22, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C ShenN Liu
Mar 26, 2010·The New England Journal of Medicine·Wenying YangUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Oct 30, 2010·Circulation Research·Ferdinando Giacco, Michael Brownlee
Dec 7, 2010·Trends in Cardiovascular Medicine·Caroline S Fox
Jul 4, 2012·Journal of Translational Medicine·Tzu-Hsien TsaiHon-Kan Yip
Jan 24, 2013·Diabetes Care·Thomas HörtenhuberGerit-Holger Schernthaner
Mar 8, 2013·Free Radical Biology & Medicine·Richard M CubbonMark T Kearney
Jul 8, 2014·Clinical Therapeutics·Néstor H GarcíaLuis J Armando
Dec 21, 2014·Journal of Physiology and Biochemistry·Francesca BonafèClaudio Muscari
Feb 18, 2015·The Journal of Clinical Hypertension·Yang ZhenHaitao Zeng
Jul 19, 2016·International Journal of Stem Cells·Maria Rosaria De PascaleClaudio Napoli

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Citations

Dec 15, 2020·World Journal of Cardiology·Christos KourekStavros Dimopoulos

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