Attenuated endothelium-mediated relaxation by acteoside in rat aorta: Role of endothelial [Ca2+]i and nitric oxide/cyclic GMP pathway

Life Sciences
Chi Wai LauYu Huang

Abstract

Acteoside and other phenylethanoid glycoside are contained in many plants that are widely used in traditional Chinese herbal medicine. Acteoside possesses multiple biological actions. Its effect on the vascular system is, however, incompletely understood. This study was aimed to investigate the role of endothelial [Ca2+]i, nitric oxide (NO), and cyclic GMP in acteoside-induced inhibition of endothelial NO-mediated relaxation in rat aorta. Acteoside reduced endothelial NO-dependent relaxation induced by acetylcholine (Ach) or A23187. Acteoside inhibited Ach-stimulated increase in tissue content of cyclic GMP in endothelium-intact rings. L-NNA abolished the stimulatory effect of Ach. Treatment with acteoside significantly suppressed bradykinin-induced increase in [Ca2+]i of cultured rat aortic endothelial cells. Acute exposure to acteoside (30 microM) did not affect the expression of eNOS mRNA in endothelium-intact rings. In summary, acteoside impairs endothelial NO-mediated aortic relaxation partially through inhibition of agonist-induced endothelial Ca2+ mobilization and Ca2+-dependent NO production and subsequent suppression of cyclic GMP formation. This novel pharmacological action if occurring in small vessels in vivo, may c...Continue Reading

Citations

Jul 13, 2006·Archives of Pharmacal Research·Jin Hee LeeSang Soo Sim
Sep 19, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karel SmejkalMargita Dvorska
Mar 16, 2011·The Journal of Pharmacy and Pharmacology·Benedetta IsacchiAnna Rita Bilia
Jun 5, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hasandeep SinghBalbir Singh

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