PMID: 8602673Feb 1, 1996Paper

Attenuated hypoxic pulmonary vasoconstriction during isoflurane anesthesia is abolished by cyclooxygenase inhibition in chronically instrumented dogs

Anesthesiology
P F Lennon, P A Murray

Abstract

Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism whereby gas exchange is improved through the diversion of blood flow away from poorly oxygenated regions of the lung. The effect of isoflurane anesthesia on HPV is unclear. Using a chronically instrumented canine model, it was hypothesized that isoflurane anesthesia would attenuate HPV compared to the response measured in the same animal in the conscious state. Moreover, because volatile anesthetics increase the production of cyclooxygenase metabolites, it was hypothesized that attenuation of HPV during isoflurane anesthesia would be abolished by cyclooxygenase inhibition. Left pulmonary vascular pressure-flow plots were generated in chronically instrumented dose by measuring the pulmonary vascular pressure gradient (pulmonary arterial pressure-left atrial pressure) and left pulmonary blood flow during inflation of a hydraulic occluder implanted around the right main pulmonary artery. In protocol 1 (n - 7), left pulmonary vascular pressure-flow plots were generated during normoxia and hypoxia (systemic arterial PO2 approximately 50 mmHg) in the conscious and isoflurane-anesthetized states. In protocol 2 (n = 7), left pulmonary vascular pressure-flow plots were ...Continue Reading

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Citations

Jun 16, 2012·Der Anaesthesist·B PreckelM W Hollmann
May 15, 2003·The Journal of Emergency Medicine·N Stuart HarrisStephen H Thomas
Aug 5, 1998·Acta Anaesthesiologica Scandinavica·W KarzaiH J Priebe
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Nov 26, 2003·Anesthesiology·Gilbert BlaiseBernard Hubert
Nov 20, 2009·European Journal of Anaesthesiology·Cornelius J BuschJörg Weimann
Jun 29, 2011·European Journal of Anaesthesiology·Christian S Bruells, Rolf Rossaint
Sep 29, 2012·Journal of Veterinary Emergency and Critical Care·Ainsley E BoudreauRon J Johnson
May 21, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·F KerbaulF Gouin
Jan 15, 2015·Anesthesiology·Andrew B Lumb, Peter Slinger
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Jan 21, 2000·Journal of Applied Physiology·S DoiP A Murray
Oct 3, 2006·Current Opinion in Anaesthesiology·J B Eisenkraft
Aug 12, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Catharina SchreiberDiana Bonderman

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