PMID: 9451468Feb 6, 1998Paper

Attenuated neutrophil respiratory burst following acute hypoglycaemia in diabetic patients and normal subjects

Acta Diabetologica
G A ThomsonS J Gallacher

Abstract

The effects of insulin-induced hypoglycaemia on the neutrophil respiratory burst were investigated in six patients with type 1 diabetes and six non-diabetic control subjects. Plasma glucose reached similar nadirs in control subjects (0.9 +/- 0.1 mmol 1(-1); mean +/- SEM) and diabetic patients (1.2 +/- 0.2 mmol 1(-1)) (NS). The resting neutrophil respiratory burst was similar in control subjects (1.26 +/- 0.15 mV) and diabetic patients (1.03 +/- 0.18 mV) (NS). The neutrophil respiratory burst fell following hypoglycaemia in control subjects and diabetic patients to 0.38 +/- 0.05 mV (P < 0.001) and 0.54 +/- 0.09 mV (P < 0.05), respectively. This fall was significantly greater in control subjects (ANOVA; P < 0.001). Resting neutrophil counts were not significantly different in control subjects (3.2 +/- 0.3 x 10(9) 1(-1)) and diabetic patients (6.1 +/- 1.5 x 10(9) 1(-1)). Following hypoglycaemia, neutrophil numbers increased in control subjects and diabetic patients to 11.5 +/- 1.4 x 10(9) 1(-1) (P < 0.01) and 9.7 +/- 1.7 x 10(9) 1(-1) (P < 0.05), respectively. This increase was significantly greater in control subjects (ANOVA; P < 0.001). These results suggest that the neutrophil respiratory burst is suppressed in response to hypo...Continue Reading

Citations

Oct 22, 2010·Cell Biochemistry and Biophysics·Elena MatteucciOttavio Giampietro
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Peter MancusoMarc Peters-Golden
Aug 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Regula MeierJohn F Stover
Mar 31, 2010·Leukemia & Lymphoma·Charulata RamaprasadDavid L Pitrak
Aug 21, 2007·Diabetes Research and Clinical Practice·S BilgicG Deniz
May 18, 2016·Journal of Diabetes Investigation·Juan HuangZhiguang Zhou
Sep 4, 2004·Journal of Leukocyte Biology·S WalrandM-P Vasson
Feb 23, 2008·Molecular Nutrition & Food Research·Tomoko Oya-ItoNorio Ohashi
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Stéphane WalrandMarie-Paule Vasson
Jul 11, 2021·Diabetes/metabolism Research and Reviews·Anna GiovenzanaNick Giannoukakis
May 23, 2006·Metabolism: Clinical and Experimental·Vladimíra FejfarováTerezie Pelikánová

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