Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Heikki V HuikuriCARISMA and REFINE Investigators

Abstract

Autonomic dysfunction tends to improve over time after acute myocardial infarction (MI), but the clinical significance of autonomic remodeling is not well known. The purpose of this study was to test the hypothesis that the amount of recovery of autonomic function early after MI is associated with a risk for serious arrhythmias. The prognostic significance of autonomic remodeling after MI was assessed in one post-MI cohort [Cardiac Arrhythmia and Risk Stratification after Myocardial Infarction (CARISMA)] and validated in a second cohort [Risk Estimation After Infarction, Noninvasive Evaluation (REFINE)]. Changes in heart rate variability (DeltaHRV) and heart rate turbulence (DeltaHRT) were measured from 24-hour ECG recordings performed early (5-21 days) and later (6 weeks) after MI in CARISMA (n = 312). DeltaHRV and DeltaHRT were similarly measured from early (2-4 weeks) and later (10-14 weeks) post-MI recordings in REFINE (n = 322). HRV and HRT increased over time in both cohorts. Attenuated recovery of autonomic function, defined as DeltaHRT slope <2.0 ms/RR, was associated with a 9.4-fold (95% confidence interval 1.2-71.6; P = .03) higher risk of ECG-documented sustained ventricular tachycardia or ventricular fibrillation in...Continue Reading

References

Dec 11, 1991·Journal of the American College of Cardiology·J T BiggerW J Schneider
Aug 18, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·M V Pitzalis
Jul 4, 2002·Clinical Science·Gian Domenico PinnaMaria Teresa La Rovere
Aug 23, 2003·Journal of the American College of Cardiology·Heikki V HuikuriRobert J Myerburg
Aug 27, 2003·Circulation·Petra BarthelGeorg Schmidt
Oct 4, 2005·Journal of the American College of Cardiology·Gian Domenico PinnaMaria Teresa La Rovere
Dec 11, 2007·Journal of the American College of Cardiology·Derek V ExnerUNKNOWN REFINE Investigators
Jan 22, 2009·European Heart Journal·Heikki V HuikuriUNKNOWN Cardiac Arrhythmias and Risk Stratification after Acute Myocardial Infarction study group

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Citations

May 27, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Heikki V Huikuri
Feb 7, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Claudia LermaHeikki V Huikuri
May 8, 2014·European Heart Journal·Hein J J WellensArthur A Wilde
Dec 3, 2014·Revista Española De Cardiología·Iwona Cygankiewicz, Pawel Ptaszynski
Aug 21, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tim Wollenweber, Frank M Bengel
Jul 23, 2014·Clinical and Experimental Hypertension : CHE·Sharanya RameshSofia B Ahmed
Aug 28, 2015·Current Medical Research and Opinion·Andrei Brateanu
Nov 13, 2013·Progress in Cardiovascular Diseases·Iwona Cygankiewicz
Nov 13, 2013·Progress in Cardiovascular Diseases·Heikki V Huikuri, Phyllis K Stein
Feb 5, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masamichi Hirose
Apr 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R D VanderlaanA I Dipchand
Oct 24, 2013·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Mohamed Moussa ArishaPhilippe Chevalier
Mar 29, 2014·Clinical Physiology and Functional Imaging·Camila Bianca Falasco PantoniAudrey Borghi-Silva
Dec 15, 2015·The Journal of Physiology·Claudia Lerma, Leon Glass
May 13, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jonathan S SteinbergRyszard Piotrowicz
Jul 30, 2014·Journal of Cardiovascular Translational Research·Gaetano M De FerrariPeter J Schwartz
Jun 3, 2011·Circulation·Jeffrey J GoldbergerDouglas P Zipes
Jun 3, 2020·Physiological Measurement·Valeria BlesiusAndreas Dominik
May 25, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Angelo AuricchioUNKNOWN collaborative study group
May 10, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jonathan S SteinbergRyszard Piotrowicz
Aug 18, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Bert VandenberkRik Willems
Oct 13, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Iosif XenogiannisDimitrios Alexopoulos
Apr 10, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Agustín Manresa-RocamoraManuel Moya-Ramón
Jul 14, 2021·Herzschrittmachertherapie & Elektrophysiologie·Heikki Huikuri
Aug 1, 2021·Cardiac Electrophysiology Clinics·Arjun N Sharma, Adrian Baranchuk

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