PMID: 1971811Jun 1, 1990

Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats

Hypertension
R A FelderP A Jose

Abstract

Activation of renal dopamine-1 receptors decreases sodium transport. However, the spontaneously hypertensive rat retains sodium despite increased renal dopamine concentration. We tested the hypothesis that the abnormal sodium handling in spontaneously hypertensive rats (Okamoto-Aoki strain) is related to a decreased dopaminergic response by studying the effects of the intrarenal infusion of the dopamine-1 agonist SKF-38393 and the dopamine-1 antagonist SCH-23390 in hypertensive and in normotensive Wistar-Kyoto rats. Rats (9-16 weeks old) were studied with renal nerves intact under pentobarbital anesthesia (n = 5-6 in each group). Specificity of dopamine-1 effects of SKF-38393 was verified because its natriuretic effect was blocked in a dose-related manner by the dopamine-1 antagonist SCH-23390 (n = 5). Intrarenal but resulted in a dose-related natriuresis and diuresis in normotensive but not in hypertensive rats. Intrarenal arterial infusion of the dopamine-1 antagonist SCH-23390 alone induced an antinatriuresis, without affecting glomerular filtration rate, in normotensive but not in hypertensive rats. Addition of the dopamine-2 antagonist YM-09151 to the dopamine-1 antagonist infusion did not enhance the effect of the dopamin...Continue Reading

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Citations

Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P A JoseR A Felder
Jul 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiaoyan WangPedro A Jose
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Jun 3, 2011·Current Hypertension Reports·Mohammad AsgharTahir Hussain
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Mar 3, 1999·Clinical and Experimental Hypertension : CHE·Tahir HussainM F Lokhandwala
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Oct 12, 2010·American Journal of Physiology. Renal Physiology·Abdul Bari MuhammadAnees Ahmad Banday
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