Attenuated response to cold of brown adipose tissue of mice made obese with gold thioglucose

Canadian Journal of Physiology and Pharmacology
J Eley, J Himms-Hagen

Abstract

In a first study, mice made obese with gold thioglucose became hypothermic when exposed to 4 degrees C. In a second study, lean mice and mice made obese with gold thioglucose (dynamic phase) were acclimated to 14 degrees C for up to 2 weeks and their brown adipose tissue was studied. The cold-induced increase in thyroxine 5'-deiodinase activity was initially slightly smaller in obese mice, but by 24 h and 2 weeks in the cold the activity of thyroxine 5'-deiodinase was the same in lean and obese mice. Unexpectedly, the elevated activity of 5'-deiodinase returned to the low level seen in warm-acclimated mice in both lean and obese mice after 2 weeks of cold acclimation. In gold thioglucose obese mice, a progressive cold-induced increase in the binding of guanosine diphosphate to isolated mitochondria, an index of both acute thermogenic activation and a long-term increase in uncoupling protein concentration, paralleled that seen in normal lean mice and remained at a high level after 2 weeks in the cold, although still remaining slightly lower than normal. It is not clear how a high level of mitochondrial GDP binding is maintained in cold-acclimated mice at the same time as a low level of thyroxine 5'-deiodinase activity when both ...Continue Reading

Citations

Jan 1, 1991·Journal of Pineal Research·K A StokkanR J Reiter
Apr 6, 2006·American Journal of Physiology. Endocrinology and Metabolism·Valeria GolozoubovaJan Nedergaard
Jul 1, 1989·The American Journal of Physiology·I R ParkJ Himms-Hagen
Jun 1, 1989·The American Journal of Physiology·J Eley, J Himms-Hagen
Jan 1, 1989·Progress in Lipid Research·J Himms-Hagen

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