Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.

Infection and Immunity
David E LanarJ Sadoff

Abstract

NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vivo CD8+ T-cell depletion. Protection was not enhanced by modification of the subcellular localization of CSP. These results suggest the potential of poxvirus-based vectors for the development of vaccine candidates for human malaria.

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Aug 1, 1997·Immunology and Cell Biology·S L HoffmanR C Hedstrom
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard J AndersonAdrian V S Hill
Jun 18, 2014·Frontiers in Microbiology·Natalija Van Braeckel-Budimir, John T Harty
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