Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats

Immunopharmacology and Immunotoxicology
Engy M El MorsyMaha A E Ahmed

Abstract

Ulcerative colitis is a chronic inflammatory bowel disease. Recent studies reported a pivotal role of elevated intracellular calcium in this disorder. Coenzyme Q10 (CoQ10) and amlodipine are known to maintain cellular energy, decrease intracellular calcium concentration in addition to their antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the possible protective effects of CoQ10, amlodipine and their combination on ulcerative colitis. Colitis was induced in rats by intracolonic injection of 3% acetic acid. CoQ10 (10 mg/kg), amlodipine (3 mg/kg) and their combination were administered for 8 consecutive days before induction of colitis. Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. On the other hand, they increased superoxide dismutase (SOD) activity, adenosine-5'-triphosphate (ATP) and interleukin-10 (IL-10) colonic contents. Administration of either CoQ10 o...Continue Reading

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Citations

Nov 2, 2015·Redox Biology·Fabiana Andréa MouraMarília Oliveira Fonseca Goulart
Jun 14, 2016·HIV Clinical Trials·Justin T MorrisonGrace A McComsey
Oct 22, 2018·Journal of Exercise Nutrition & Biochemistry·Ragip PalaKazim Sahin
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Nov 2, 2021·Journal of Biochemical and Molecular Toxicology·Marwa E El-ShamarkaMaha A E Ahmed

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