Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats

Neuroscience Letters
Yiwen GuXiangrui Wang

Abstract

Increasing evidences approve the long-term analgesia effects of intrathecal lidocaine in patients with chronic pain and in animal peripheral nerve injury models, but the underlying mechanism remains elusive. Previous evidences suggest that the activation of the p38 MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord involves in nerve injury-induced neuropathic pain. In this study, we demonstrate that attenuating phosphorylation of p38 MAPK in the activated microglia of spinal cord, at least partly, is the mechanism of intrathecal lidocaine reversing established tactile allodynia in chronic constriction injury model of rats. This finding not only provides a new insight into the mechanisms underlying long-term therapeutic effects of lidocaine on neuropathic pain, but also reveals one more specific drug target for analgesia.

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Citations

Aug 18, 2010·International Journal of Medical Sciences·Fei-xiang WuWei-feng Yu
Mar 24, 2009·Glia·Kazuhide Inoue, Makoto Tsuda
Aug 24, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Yi LiangJun-Fan Fang
Jun 3, 2020·Life Sciences·Lijia MaiWenguo Fan
Jul 1, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ji-Hee YeoDae-Hyun Roh

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