Abstract
The purpose of this study was to investigate roles of the anti-inflammatory cytokine interleukin (IL) 10 and the proinflammatory cytokines IL-1β and tumor necrosis factor α (TNF-α) in spinal manipulation-induced analgesic effects of neuropathic and postoperative pain. Neuropathic and postoperative pain were mimicked by chronic compression of dorsal root ganglion (DRG) (CCD) and decompression (de-CCD) in adult, male, Sprague-Dawley rats. Behavioral pain after CCD and de-CCD was determined by the increased thermal and mechanical hypersensitivity of the affected hindpaw. Hematoxylin and eosin staining, whole-cell patch clamp electrophysiological recordings, immunohistochemistry, and enzyme-linked immunosorbent assay were used to examine the neural inflammation, neural excitability, and expression of c-Fos and PKC as well as levels of IL-1β, TNF-α, and IL-10 in blood plasma, DRG, or the spinal cord. We used the activator adjusting instrument, a chiropractic spinal manipulative therapy tool, to deliver force to the spinous processes of L5 and L6. After CCD and de-CCD treatments, the animals exhibited behavioral and neurochemical signs of neuropathic pain manifested as mechanical allodynia and thermal hyperalgesia, DRG inflammation, ...Continue Reading
References
Mar 1, 1995·Issues in Mental Health Nursing·A Henderson
Nov 28, 1996·Nature·S NeumannC J Woolf
Oct 26, 2000·Journal of Manipulative and Physiological Therapeutics·T S KellerA W Fuhr
Nov 9, 2000·Pain·J G CuiB Linderoth
Apr 5, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·H BrisbyB Rydevik
Aug 21, 2003·Pain·Xue-Jun SongRobert H LaMotte
Sep 17, 2003·Journal of Manipulative and Physiological Therapeutics·Xue-Jun SongRonald L Rupert
Mar 1, 2005·Pain·Zheng-Bei WangXue-Jun Song
Jan 7, 2006·Journal of Manipulative and Physiological Therapeutics·Xue-Jun SongRonald L Rupert
Jan 7, 2006·Journal of Manipulative and Physiological Therapeutics·Julita A Teodorczyk-InjeyanRichard Ruegg
Oct 6, 2006·Journal of Neurophysiology·Ji-Hong ZhengXue-Jun Song
Nov 13, 2007·Journal of Manipulative and Physiological Therapeutics·Thomas S EaganPaul R Standley
Mar 7, 2008·European Journal of Pain : EJP·Xue-Jun SongLi-Ze Xiong
May 2, 2008·Pain·Xue-Jun SongZhi-Jiang Huang
Nov 26, 2008·Molecular Pain·Yuan HanXue-Jun Song
Feb 6, 2009·Anesthesiology·Xue-Song SongXue-Jun Song
May 11, 2011·Cancer Research·Su LiuXue-Jun Song
Oct 8, 2011·Journal of Manipulative and Physiological Therapeutics·Julita A Teodorczyk-InjeyanH Stephen Injeyan
May 1, 2012·Pain·Zhi-Jiang HuangXue-Jun Song
Apr 16, 2013·The Journal of Clinical Investigation·Yan-Kai ZhangXue-Jun Song
Aug 27, 2013·Pain·Su LiuXue-Jun Song
Sep 21, 2013·Journal of Manipulative and Physiological Therapeutics·Thanh V CaoPaul R Standley
Jul 8, 2014·Journal of Manipulative and Physiological Therapeutics·Cynthia K PetersonRolf Nussbaumer
Dec 10, 2014·Journal of Manipulative and Physiological Therapeutics·Carolina KolbergWania A Partata
Jan 9, 2015·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Anupama KizhakkeveettilGena E Kadar
Sep 26, 2015·Pain·Su LiuXue-Jun Song
Citations
Jun 25, 2019·The Journal of the American Osteopathic Association·Christopher LarrimoreAlison Bested
May 28, 2020·Frontiers in Neuroscience·Carla Rigo LimaWilliam Ray Reed
Jul 9, 2017·Experimental Brain Research·William R ReedRandall S Sozio
Dec 25, 2019·Journal of Chiropractic Humanities·Robert A Leach
Apr 1, 2021·European Journal of Pain : EJP·Carlos Gevers-MontoroMathieu Piché
Jun 10, 2021·Pain Reports·Ivo J Lutke SchipholtGwendolyne G M Scholten-Peeters
Jun 25, 2021·European Journal of Applied Physiology·Heidi HaavikBernadette Murphy