Attenuation Effect of Spinal Manipulation on Neuropathic and Postoperative Pain Through Activating Endogenous Anti-Inflammatory Cytokine Interleukin 10 in Rat Spinal Cord

Journal of Manipulative and Physiological Therapeutics
Xue-Jun SongRonald L Rupert

Abstract

The purpose of this study was to investigate roles of the anti-inflammatory cytokine interleukin (IL) 10 and the proinflammatory cytokines IL-1β and tumor necrosis factor α (TNF-α) in spinal manipulation-induced analgesic effects of neuropathic and postoperative pain. Neuropathic and postoperative pain were mimicked by chronic compression of dorsal root ganglion (DRG) (CCD) and decompression (de-CCD) in adult, male, Sprague-Dawley rats. Behavioral pain after CCD and de-CCD was determined by the increased thermal and mechanical hypersensitivity of the affected hindpaw. Hematoxylin and eosin staining, whole-cell patch clamp electrophysiological recordings, immunohistochemistry, and enzyme-linked immunosorbent assay were used to examine the neural inflammation, neural excitability, and expression of c-Fos and PKC as well as levels of IL-1β, TNF-α, and IL-10 in blood plasma, DRG, or the spinal cord. We used the activator adjusting instrument, a chiropractic spinal manipulative therapy tool, to deliver force to the spinous processes of L5 and L6. After CCD and de-CCD treatments, the animals exhibited behavioral and neurochemical signs of neuropathic pain manifested as mechanical allodynia and thermal hyperalgesia, DRG inflammation, ...Continue Reading

References

Oct 26, 2000·Journal of Manipulative and Physiological Therapeutics·T S KellerA W Fuhr
Apr 5, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·H BrisbyB Rydevik
Sep 17, 2003·Journal of Manipulative and Physiological Therapeutics·Xue-Jun SongRonald L Rupert
Jan 7, 2006·Journal of Manipulative and Physiological Therapeutics·Xue-Jun SongRonald L Rupert
Jan 7, 2006·Journal of Manipulative and Physiological Therapeutics·Julita A Teodorczyk-InjeyanRichard Ruegg
Oct 8, 2011·Journal of Manipulative and Physiological Therapeutics·Julita A Teodorczyk-InjeyanH Stephen Injeyan
Apr 16, 2013·The Journal of Clinical Investigation·Yan-Kai ZhangXue-Jun Song
Jul 8, 2014·Journal of Manipulative and Physiological Therapeutics·Cynthia K PetersonRolf Nussbaumer
Dec 10, 2014·Journal of Manipulative and Physiological Therapeutics·Carolina KolbergWania A Partata
Jan 9, 2015·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Anupama KizhakkeveettilGena E Kadar

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