Attenuation of abnormalities in the lipid metabolism during experimental myocardial infarction induced by isoproterenol in rats: beneficial effect of ferulic acid and ascorbic acid

Basic & Clinical Pharmacology & Toxicology
Surinder Kumar YogeetaThiruvengadam Devaki

Abstract

The present study aims at evaluating the effect of the combination of ferulic acid and ascorbic acid on isoproterenol-induced abnormalities in lipid metabolism. The rats were divided into eight groups: Control, isoproterenol, ferulic acid alone, ascorbic acid alone, ferulic acid+ascorbic acid, ferulic acid+isoproterenol, ascorbic acid+isoproterenol and ferulic acid+ascorbic acid+isoproterenol. Ferulic acid (20 mg/kg b.w.t.) and ascorbic acid (80 mg/kg b.w.t.) both alone and in combination was administered orally for 6 days and on the fifth and the sixth day, isoproterenol (150 mg/kg b.w.t.) was injected intraperitoneally to induce myocardial injury to rats. Induction of rats with isoproterenol resulted in a significant increase in the levels of triglycerides, total cholesterol, free fatty acids, free and ester cholesterol in both serum and cardiac tissue. A rise in the levels of phospholipids, lipid peroxides, low density lipoprotein and very low density lipoprotein-cholesterol was also observed in the serum of isoproterenol-intoxicated rats. Further, a decrease in the level of high density lipoprotein in serum and in the phospholipid levels, in the heart of isoproterenol-intoxicated rats was observed, which was paralleled by a...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 30, 1975·Annals of the New York Academy of Sciences·E Ginter
Jan 1, 1990·Advances in Experimental Medicine and Biology·B FreiB N Ames
Feb 14, 1973·Biochimica Et Biophysica Acta·H V KothariD Kritchevsky
Sep 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·J HitzG Siest
Dec 1, 1980·Archives of Biochemistry and Biophysics·K R ChienJ L Farber
Jul 1, 1994·The American Journal of Clinical Nutrition·J HallfrischR Andres
Jun 21, 1996·Molecular and Cellular Biochemistry·C Nirmala, R Puvanakrishnan
Jun 17, 1998·Journal of the American College of Nutrition·J A Simon, E S Hudes
Dec 22, 1999·The Proceedings of the Nutrition Society·M Chopra, D I Thurnham
Oct 29, 2000·Journal of Agricultural and Food Chemistry·M I GilA A Kader
Nov 13, 2001·Journal of the American College of Cardiology·J ShiteC Liang
May 16, 2002·Journal of Agricultural and Food Chemistry·Rebeca GarciaJacques Nicolas
Mar 7, 2003·Molecular and Cellular Biochemistry·Venkatachalem SathishThiruvengadam Devaki
Feb 24, 2004·Journal of Medicinal Food·John ShiYukio Kakuda
Jul 1, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K H Sabeena FarvinT K Thankappan

❮ Previous
Next ❯

Citations

Jan 12, 2008·Journal of Clinical Biochemistry and Nutrition·Marimuthu SrinivasanVenugopal P Menon
Apr 20, 2014·Mediators of Inflammation·Assunta RaiolaAmalia Barone
May 7, 2013·Expert Opinion on Investigational Drugs·Lokesh PathakAshish Dhir
Apr 22, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Pandima Devi Sampath, Kannan Vijayaragavan
Feb 7, 2008·The Journal of Pharmacy and Pharmacology·Periyathambi Thangappan Devika, Ponnian Staneley Mainzen Prince
Jul 22, 2010·Pharmaceutical Biology·Rahila AhmadUma Bhandari
Jun 5, 2012·European Journal of Pharmacology·Manikandan RamarBaskaralingam Vaseeharan
Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Assunta RaiolaMaria Manuela Rigano
Jan 19, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Qishu JiaoBin Liu
May 16, 2017·BioMed Research International·Gihyun Lee, Hyunsu Bae
Sep 23, 2014·Human & Experimental Toxicology·S HassaniK Razavi-Azarkhiavi
Oct 23, 2020·Critical Reviews in Food Science and Nutrition·Sanskriti VatsRupesh Deshmukh
Nov 5, 2014·Journal of Agricultural and Food Chemistry·Maria Manuela RiganoAmalia Barone
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Somayeh JavidanpourSeyyed Ali Mard

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.