Attenuation of adhesion, quorum sensing and biofilm mediated virulence of carbapenem resistant Escherichia coli by selected natural plant products

Microbial Pathogenesis
Pallavi ThakurRakesh Kumar Sharma

Abstract

The multi-drug resistance offered by Carbapenem Resistant Escherichia coli (Family: Enterobacteriaceae; Class: Gammaproteobacteria) against third line antibiotics can be attributed towards its ability to develop biofilm. Such process involves adhesion and quorum-sensing induced colonization leading to biomass development. The present study explored the anti-adhesion, anti-quorum sensing and anti-biofilm potential of 05 pre-standardized potent herbals. Berberis aristata (PTRC-2111-A) exhibited maximum potential in all these activities i.e. 91.3% ± 0.05% (Anti-adhesion), 96.06% ± 0.05% (Anti-Quorum sensing) and 51.3% ± 0.07% (Anti-Biofilm formation) respectively. Camellia sinensis (PTRC-31911-A) showed both anti-adhesion (84.1% ± 0.03%) and anti-quorum sensing (90.0%) potential while Holarrhena antidysenterica (PTRC-8111-A) showed only anti-quorum sensing potential as compared to standards/antibiotics. These findings were in line with the molecular docking analysis of phytoligands against Lux S and Pilin receptors. Furthermore, the pairwise correlation analysis of the tested activities with qualitative, quantitative and bioactivity functional descriptors revealed that an increased content of alkaloid, moderate content of flavonoi...Continue Reading

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Citations

Jan 21, 2017·Genes·Meredith SchroederAmanda E Brooks
Jul 22, 2016·The Journal of Bone and Joint Surgery. American Volume·Arvind NanaAntonia F Chen
Aug 2, 2020·The Journal of Pharmacy and Pharmacology·Francisca B M SousaJand V R Medeiros
Sep 26, 2017·Asian Pacific Journal of Tropical Medicine·Abdelhakim BouyahyaYoussef Bakri
Jun 6, 2018·Frontiers in Microbiology·Serena GaliéFelipe Lombó

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