PMID: 2508164Jan 1, 1989Paper

Attenuation of anorexia induced by heat or surgery during sustained administration of ginsenoside Rg1 into rat third ventricle

Psychopharmacology
K FujimotoH Machidori

Abstract

Effects of ginsenoside Rg1 (Rg1), a major component of panax ginseng, on modulation of ingestive behavior were investigated. No direct effect was observed on food intake after 10 microliters infusion of 1.0, 2.0, 4.0 or 8.0 mM Rg1 into the rat third ventricle for 10 min. Continuous osmotic infusion of 4.0 mM Rg1 at a rate of 0.966 microliter/h into the third ventricle prevented feeding suppression caused by surgical procedure to implant an osmotic minipump. Continuous infusion of Rg1 attenuated anorexia, increased water intake, and decreased ambulation, that were produced by elevation of environmental temperature from 21 degrees C to 30 degrees C. Consequently, rats maintained body weight and rectal temperature unchanged. The results indicate that sustained central administration of Rg1 may relieve anorexia caused by implantation surgery or by a heated environment.

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Citations

Sep 1, 1993·Physiology & Behavior·H YoshimatsuT Sakata
Jan 1, 1994·Brain Research Bulletin·T SakataH Yoshimatsu
Oct 26, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanumantha Rao Balaji RaghavendranChang-Gue Son
Nov 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kui-Jin KimBoo-Yong Lee
Feb 15, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Chunhoo CheonSeong-Gyu Ko
Nov 1, 1995·Obesity Research·T Sakata
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Francisco SalaSalvador Sala
May 6, 2020·Molecular Genetics & Genomic Medicine·Stefano PaolacciMatteo Bertelli

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