Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of beta-adrenoceptor blockade

Journal of Hypertension
Giuseppe MaranoAlberto U Ferrari

Abstract

Racemic propranolol attenuates cardiac hypertrophy secondary to abdominal aortic banding-induced pressure overload by a mechanism independent of its effect on cardiac work load. This was only observed, however, using doses of propranolol that were much higher than those needed to induce beta-adrenoceptor blockade. Thus, the question remains as to whether the antihypertrophic effect of propranolol depends on its ability to antagonize cardiac beta-adrenoceptor-mediated action (positive chronotropic effect, trophic effect) or on beta-adrenoceptor-independent action. In a rat model of chronic pressure overload induced by abdominal aortic banding, we evaluated the effects on left ventricular hypertrophy (LVH) of the propranolol isomers, L-propranolol and D-propranolol, which compared to L-isomer is approximately 50-fold less potent as a beta-adrenoceptor antagonist, but is similarly potent as a membrane-stabilizer, as well as of timolol, a non-selective beta-adrenergic antagonist devoid of membrane stabilizing activity, and disopyramide, which is a membrane stabilizer, but not a beta-adrenoceptor blocker. Compared to sham-operated rats, banded rats had 30% greater left ventricular to body weight (LVW/BW) ratio (P < 0.01). The increa...Continue Reading

References

Oct 1, 1979·Circulation·R L WoosleyJ A Oates
May 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·B O'Rourke, D K Reibel
Jul 1, 1991·Cardiovascular Research·P K Ganguly, G R Sherwood
Oct 1, 1988·The American Journal of Physiology·V Fatigati, M J Peach
Jun 1, 1969·British Journal of Pharmacology·A N DohadwallaE M Vaughan Williams
Jun 25, 1966·Nature·R Howe, R G Shanks
Dec 1, 1983·Journal of the American College of Cardiology·H J DuffR L Woosley
May 19, 1993·European Journal of Pharmacology·A N HoqueY Abiko

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Citations

May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Fernanda B M PrivieroEdson Antunes
Dec 17, 2011·The Journal of Surgical Research·Brett E LarsonKalev Freeman
May 28, 2011·British Journal of Pharmacology·Marco MusumeciGiuseppe Marano
Apr 26, 2003·Pflügers Archiv : European journal of physiology·Giuseppe MaranoAlberto U Ferrari
Mar 9, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Simon SchallaMaythem Saeed
Apr 10, 2008·Journal of Hypertension·Jane-Lise Samuel, Bernard Swynghedauw
Apr 10, 2008·Journal of Hypertension·Claudia GiampietriElio Ziparo
Sep 29, 2007·The Journal of Pharmacology and Experimental Therapeutics·Vlad CiobotaruDamien Logeart

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