Attenuation of brain response to heroin correlates with the reinstatement of heroin-seeking in rats by fMRI

NeuroImage
Feng LuoShi-Jiang Li

Abstract

Thirty male Sprague-Dawley rats were divided into two groups and trained to self-administer either saline (n = 14) or heroin (0.1 mg/kg per injection, n = 16) for 10-12 days until a stable self-administration (SA) behavior was achieved. After 8-9 days of withdrawal, each group was divided into two subgroups for reinstatement tests and functional magnetic resonance image (fMRI) scanning, respectively, to determine the neural correlates of the reinstatement of heroin-seeking behavior. For reinstatement testing, heroin-SA rats (n = 10) displayed robust reinstatement of drug-seeking behavior triggered by an acute heroin priming injection, whereas saline control rats (n = 8) did not show such a behavioral response. Regional positive or negative blood oxygen level-dependent (BOLD) signals, induced by heroin priming injection, were observed in both groups of rats during fMRI scanning. However, such heroin-induced positive BOLD signal primarily in the prefrontal cortex and parietal cortex was significantly attenuated in heroin-SA rats (n = 6) when compared to saline control rats (n = 6). Similarly, the heroin-induced negative BOLD signal in the subcortical regions, such as in the nucleus accumbens and hippocampus, was also significantl...Continue Reading

References

Jan 1, 1989·Psychopharmacology·J H JaffeM A Sherer
Mar 1, 1974·Psychological Review·R L Solomon, J D Corbit
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Oct 6, 1997·Science·G F Koob, M Le Moal
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Oct 23, 1997·Neuron·H C BreiterS E Hyman
May 6, 1999·Psychopharmacology·R SinhaS O'Malley
Dec 22, 1999·Addiction·B L Carter, S T Tiffany
Sep 1, 2000·Brain Research. Brain Research Reviews·Y ShahamJ Stewart
Nov 4, 2000·The American Journal of Psychiatry·H GaravanE A Stein
Mar 1, 2002·Pharmacological Reviews·Uri ShalevYavin Shaham
Aug 6, 2002·Neuron·Nikos LogothetisKâmil Ugurbil
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zheng-Xiong XiShi-Jiang Li
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng LuoShi-Jiang Li

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Citations

Mar 22, 2005·Psychopharmacology·C A StewardY B Shah
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magalie Lenoir, Serge H Ahmed
Jun 19, 2010·Brain : a Journal of Neurology·Jaymin UpadhyayDavid Borsook
Aug 31, 2007·Journal of Magnetic Resonance Imaging : JMRI·Feng LuoCraig F Ferris
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiping LiuShi-Jiang Li
Aug 29, 2006·Journal of Neuroscience Methods·Adam J SchwarzAngelo Bifone
Nov 18, 2005·European Journal of Pharmacology·Jennifer M BossertYavin Shaham
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Feb 11, 2015·Psychopharmacology·Christian MontanariAldo Badiani
Mar 22, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luis M Colon-PerezMarcelo Febo
Mar 1, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Patrick SanvansonReza Shaker
Oct 28, 2016·Magnetic Resonance Imaging·Julia K BrynildsenHanbing Lu

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