PMID: 11909684Mar 23, 2002Paper

Attenuation of Ca(2+)-activated ATPase and shortening velocity in hypertrophied fast twitch skeletal muscle from aged Japanese quail

Experimental Gerontology
Stephen E Alway

Abstract

The effect of aging on the in vitro contractile properties of the patagialis (PAT) muscle of 35 young adult (YA; 8 weeks of age) and 35 aged adult (AA, 110 weeks of age) Coturnix quails was examined after 0-30 days of stretch-overload. Overload was achieved by placing a weight equivalent to 12% of the birds' body weight on one wing. The contralateral wing served as the intra-animal control. Overload increased the weight of the PAT by 45.1+/-2.1% in YA, and 24.1+/-2.6% in AA. Twitch contraction time increased with loading from 43.2+/-1.2 to 67.3+/-2.2 ms in YA birds and 57.2+/-1.7 to 77.4+/-1.9 ms in AA birds. Unloaded shortening velocity (Vo) decreased by 40.1+/-2.2 and 38.8+/-3.2% in YA and aged birds, respectively. The decrease in fast myosin expression was greater in overloaded muscles of YA (20%) as compared to AA birds (12%). However, this was accompanied by a greater decrease in total muscle ATPase activity in aged birds (61%) compared to YA birds (40%). Myosin isozyme Ca(2+)-ATPase activity was 26% lower in FM1 but not other fast myosins in YA birds, but it was approximately 30% lower in all fast myosins in PAT muscles of aged birds. These data show that the reduction of Vo and the increase in twitch duration with aging ...Continue Reading

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Citations

Aug 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Parco M SiuStephen E Alway
Apr 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Janna R JacksonStephen E Alway
Dec 27, 2005·Experimental Gerontology·Parco M Siu, Stephen E Alway
Mar 14, 2003·Muscle & Nerve·Hans Degens, Stephen E Alway
Dec 17, 2004·American Journal of Physiology. Cell Physiology·Parco M Siu, Stephen E Alway
Jun 24, 2005·American Journal of Physiology. Cell Physiology·Parco M Siu, Stephen E Alway
Nov 19, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Stephen E AlwayDavid C Butler
Oct 16, 2004·American Journal of Physiology. Cell Physiology·Parco M SiuStephen E Alway
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephen E AlwayZsolt S Murlasits

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