Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein.

The Journal of General Virology
William C AdamsKarin Loré

Abstract

The complement-regulatory protein CD46 is the primary receptor for human adenovirus type 35 (HAdV-35) and can regulate human immune-cell activation. CD4(+) T-cells are critical for initiating and maintaining adaptive immunity elicited by infection or vaccination. It was reported previously that HAdV-35 can bind these cells and suppress their activation. The data reported here demonstrate that recombinant trimeric HAdV-35 knob proteins alone can induce CD46 receptor downregulation and inhibit interleukin-2 production and proliferation of human CD4(+) T-cells in vitro similarly to mAbs specific to the CD46 region bound by HAdV-35 knobs. A mutant knob protein with increased affinity for CD46 compared with the wild-type knob caused equivalent effects. In contrast, a CD46-binding-deficient mutant knob protein did not inhibit T-cell activation. Thus, the capacity of HAdV-35 to attenuate human CD4(+) T-cell activation depends predominantly on knob interactions with CD46 and can occur independently of infection.

References

Jan 5, 2000·Cell·F SantoroP Lusso
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G WangJ P Atkinson
Sep 6, 2003·The Journal of Biological Chemistry·Blessing Crimeen-IrwinSarah M Russell
Oct 21, 2003·Nature Medicine·Anuj GaggarAndré Lieber
May 28, 2005·Journal of Virology·Anuj GaggarAndré Lieber
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jane OliaroSarah M Russell
Dec 16, 2006·Nature Reviews. Immunology·Claudia Kemper, John P Atkinson
Jan 16, 2007·Nature Structural & Molecular Biology·B David PerssonThilo Stehle
Mar 23, 2007·Gene Therapy·F SakuraiH Mizuguchi
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karin LoréRichard A Koup
Sep 28, 2007·Journal of Virology·Hongjie WangAndré Lieber
Aug 30, 2008·Journal of Virology·Hongjie WangAndré Lieber
Oct 20, 2009·Cell Host & Microbe·Pierre-Emmanuel JoubertMathias Faure
Sep 11, 2010·FEBS Letters·Edwin D Hawkins, Jane Oliaro
Oct 30, 2010·Immunity·Margaret A Liu
Apr 15, 2011·Clinical and Experimental Immunology·J CardoneC Kemper
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·William C AdamsKarin Loré

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Citations

Oct 24, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ines BeyerAndré Lieber
Oct 23, 2012·Nature Immunology·Gaëlle Le FriecClaudia Kemper
Nov 14, 2018·The Journal of Clinical Investigation·Hongjie WangAndré Lieber
Nov 11, 2019·FEBS Letters·Chang Li, André Lieber

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