Attenuation of cocaine seeking in rats via enhancement of infralimbic cortical activity using stable step-function opsins.

Psychopharmacology
Victória A Muller EwaldRyan T LaLumiere

Abstract

The infralimbic cortex (IL) and its downstream projection target the nucleus accumbens shell (NAshell) mediate the active suppression of cocaine-seeking behavior. Although an optogenetic approach would be beneficial for stimulating the IL and its efferents to study their role during reinstatement of cocaine seeking, the use of channelrhodopsin introduces significant difficulties, as optimal stimulation parameters are not known. The present experiments utilized a stable step-function opsin (SSFO) to potentiate endogenous activity in the IL and in IL terminals in the NAshell during cocaine-seeking tests to determine how these manipulations affect cocaine-seeking behaviors. Rats first underwent 6-h access cocaine self-administration followed by 21-27 days in the homecage. Rats then underwent cue-induced and cocaine-primed drug-seeking tests during which the optogenetic manipulation was given. The same rats then underwent extinction training, followed by cue-induced and cocaine-primed reinstatements. Potentiation of endogenous IL activity did not significantly alter cue-induced or cocaine-primed drug seeking following the homecage period. However, following extinction training, enhancement of endogenous IL activity attenuated cue-i...Continue Reading

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Citations

May 10, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lifang PangHongcheng Shi
Jan 4, 2019·Psychopharmacology·Amy L Milton, Andrew Holmes
Sep 25, 2020·Physiological Reviews·Mark E BoutonGavan P McNally
Mar 25, 2020·Cold Spring Harbor Perspectives in Medicine·Matthew W FeltensteinRita A Fuchs
Jun 25, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rajtarun MadangopalBruce T Hope
Jul 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alvin S ChiuKaren K Szumlinski
Jul 3, 2021·International Journal of Molecular Sciences·Marek Schwendt, Lori A Knackstedt
Aug 21, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julian Guarque-ChabreraMarta Miquel

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