PMID: 9174653Apr 1, 1997Paper

Attenuation of contractile responses to sympathetic co-transmitters in veins from subjects with essential hypertension

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
H LindL Edvinsson

Abstract

Neuropeptide Y (NPY), noradrenaline (NA) and ATP are cotransmitters of the sympathetic nervous system and exert vasocontractile effects. The aim of this study was to determine the role of these sympathetic co-transmitters in human hypertension. Subcutaneous vessels from 12 patients with essential hypertension and 12 matched controls were studied in vitro. Vascular contractile responses to NPY, NA, alpha,beta-methylene ATP (alpha,beta-mATP) and potassium were studied in isolated arteries and veins (diameter 0.1-1.1 mm) with intact endothelium. The dilatory effect of acetylcholine was used to test the endothelial function. There was no difference in potency (pD2) or contractile response to NPY, NA or alpha,beta-mATP between hypertensive and control arteries. In veins, however, the contractile response to NPY was significantly reduced in hypertensives and the responses to NA were unchanged. Furthermore, the sensitivity (pD2) to alpha,beta-mATP was significantly reduced in veins from hypertensives. There was no difference in the dilatory response to acetylcholine between the hypertensives and the controls, neither in the arteries nor in the veins, indicating that the observed changes in vascular reactivity to NPY, NA and alpha,beta...Continue Reading

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Citations

Sep 30, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·S M Bierbower, R L Cooper
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
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Sep 14, 1999·The American Journal of Physiology·D R BrownD C Randall

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