Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats

Journal of Ethnopharmacology
Chenxue ZhangYang Yu

Abstract

Diabetic nephropathy (DN) is an acute and serious diabetic complication characterized by renal hypertrophy and renal fibrosis with the expansion of extracellular matrices. Diabetic nephropathy has become a major cause of end-stage kidney disease. Sanziguben Granule (SZGB) is a compound prescription which has been widely applied in clinical medicine for the prevention and treatment of diabetic nephropathy as well as for acute and chronic kidney injuries. However, the mechanism of protective effects of SZGB in DN remains unclear. In this research, we investigated the effects of SZGB on renal interstitial fibrosis, antioxidant proficiency, and apoptosis in streptozotocin (STZ)-induced diabetic rats. Diabetic rats were prepared by performing a right uninephrectomy along with a single intraperitoneal injection of STZ. Rats were divided into six groups including sham, DN, SZGB-D, SZGB-Z, SZGB-G and fosinopril. SZGB and fosinopril were given to rats by gavage for 12 weeks. Samples from urine, blood and kidneys were collected for biochemical, histological, immunohistochemical and western blot analyses. We found that rats treated with SZGB showed reduced 24-h urinary protein excretion along with reduced serum total cholesterol (TC) and ...Continue Reading

Citations

Sep 20, 2019·Journal of Diabetes Research·Zhenzhen LuYueyi Deng
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhonghua DongZhongxi Zhao
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Victor Udo NnaMahaneem Mohamed
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Opeyemi Joshua OlatunjiYifeng Zhou

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