Attenuation of dopamine-induced GABA release in problem gamblers

Brain and Behavior
Arne MøllerH C Lou

Abstract

We have previously shown that an interaction between medial prefrontal and parietal cortices is instrumental in promoting self-awareness via synchronizing oscillations in the gamma range. The synchronization of these oscillations is modulated by dopamine release. Given that such oscillations result from intermittent GABA stimulation of pyramidal cells, it is of interest to determine whether the dopaminergic system regulates GABA release directly in cortical paralimbic regions. Here, we test the hypothesis that the regulation of the GABA-ergic system by the dopaminergic system becomes attenuated in problem gamblers resulting in addictive behaviors and impaired self-awareness. [11 C]Ro15-4513 PET, a marker of benzodiazepine α1/α5 receptor availability in the GABA receptor complex, was used to detect changes in synaptic GABA levels after oral doses of 100mg L-dopa in a double-blind controlled study of male problem gamblers (N = 10) and age-matched healthy male controls (N = 10). The mean reduction of cortical gray matter GABA/BDZ receptor availability induced by L-dopa was significantly attenuated in the problem gambling group compared to the healthy control group (p = 0.0377). Our findings demonstrate that: (a) Exogenous dopamine...Continue Reading

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Citations

Jan 14, 2020·Addiction Biology·Nahian S ChowdhuryJustin A Harris
Feb 13, 2020·Frontiers in Systems Neuroscience·Hans C LouJean-Pierre Changeux
Feb 7, 2021·Journal of the Neurological Sciences·Yulu SongRichard A E Edden

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