PMID: 9641803Jun 26, 1998Paper

Attenuation of ECS-induced retrograde amnesia by using an herbal formulation

The Journal of ECT
A S VinekarJ S Chandra

Abstract

Earlier research indicated the efficacy of a complex herbal formulation in the attenuation of electroconvulsive shock (ECS)-induced amnestic deficits in rats; this study sought to ascertain whether a simplified herbal formulation (Memorin; Phyto-Pharma, India) also was effective. Rats pretreated for a fortnight with Memorin (200 mg/kg/day) or vehicle were exposed to a passive-avoidance learning paradigm in a shuttle box. The next day, the rats were administered two true or sham ECSs, 5 h apart; recall of the pre-ECS learning was reassessed on the following day. ECS was found to produce significant retrograde amnesia (p < 0.002). Memorin attenuated the ECS-induced amnesia (p = 0.00003) without influencing the ECS seizure duration. The clinical implications of these findings are discussed.

Citations

Oct 31, 2006·Psychopharmacology·Nandakumar NagarajaB V Venkataraman
Jul 11, 2006·Wiener medizinische Wochenschrift·Michael PrapotnikAndreas Conca
Oct 1, 2006·Indian Journal of Psychiatry·Chittaranjan Andrade, J Suresh Chandra
Aug 31, 2001·The Journal of ECT·A AnandB V Venkataraman
Apr 3, 2001·The Journal of ECT·S SudhaB V Venkataraman
Jun 27, 2000·The Journal of ECT·H A Sackeim
Apr 2, 2002·The Journal of ECT·Chittaranjan AndradeBurrah V Venkataraman

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