Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

Brain Research. Molecular Brain Research
S P HoStephen P Arneric

Abstract

Corticotropin releasing factor (CRF) is an important regulator of the endocrine, behavioral, autonomic and immune responses to stress. Two high affinity CRF receptors have been identified, which are distributed in distinct anatomical regions. CRF(1) receptors have been relatively well characterized and antagonists to this receptor effectively block stress-induced behaviors in rodents. The function of CRF(2) receptors, which are highly expressed in limbic brain regions, is less well understood. Therefore, an antisense oligonucleotide approach was used to study the role of CRF(2) receptors in the lateral septum in rats. An antisense oligonucleotide directed against the CRF(2) receptor mRNA reduced expression of CRF(2) receptors by 60--80%. In shock-induced freezing tests, animals administered the antisense oligonucleotide exhibited a significant reduction in freezing duration. However, pain sensitivity and locomotor activity were unaltered. A four-base mismatch of the antisense sequence had no significant effects on CRF(2) receptor density and on freezing behavior. These data support the involvement of CRF(2) receptors in fear conditioning. CRF(1) receptor antagonists also reduce freezing in this test. Additional studies to deter...Continue Reading

References

Jan 1, 1975·Neuroendocrinology·J P Allen, C F Allen
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·J E Sherman, N H Kalin
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K J BreslauerL A Marky
Mar 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M PerrinW Vale
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
Jun 1, 1993·Physiology & Behavior·E YadinC E Strickland
Mar 26, 1997·European Journal of Pharmacology·R S MansbachY L Chen
Jan 1, 1997·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K D DieterichE B De Souza
Jul 23, 1997·European Journal of Pharmacology·B SchöbitzR Spanagel
Mar 4, 1998·Journal of Psychosomatic Research·M BourinJ Bradwejn
Dec 17, 1998·The Journal of Endocrinology·L ArboreliusC B Nemeroff
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S C WeningerJ A Majzoub
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·J SpiessJ Radulovic
Jun 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marianne E MarshallLynn E Heasley

❮ Previous
Next ❯

Citations

Nov 5, 2005·Brain Research. Brain Research Reviews·Adrie W Bruijnzeel, Mark S Gold
May 19, 2005·Neuroscience and Biobehavioral Reviews·Martin E KeckMarianne B Müller
Nov 20, 2002·Biological Psychiatry·Justine M KentJack M Gorman
Jan 22, 2002·Neuroscience and Biobehavioral Reviews·L K Takahashi
May 10, 2003·Brain Research. Brain Research Reviews·Dirk Van OekelenJosée E Leysen
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Jun 1, 2002·Ageing Research Reviews·Guther Neeck
Aug 11, 2004·Behavioral Neuroscience·Yasushi KiyokawaYuji Mori
Nov 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria B RisbroughFlorian Holsboer
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco PapaleoAngelo Contarino
May 10, 2006·Genes, Brain, and Behavior·C StoppelO Stork
Dec 3, 2011·International Journal of Medical Sciences·Tasneem Fatema Hasan, Hunaid Hasan
Jan 25, 2014·Frontiers in Neuroendocrinology·Eric P ZorrillaGeorge F Koob
Jul 28, 2006·Hormones and Behavior·Victoria B Risbrough, Murray B Stein
Jun 24, 2004·Expert Opinion on Investigational Drugs·Eric P Zorrilla, George F Koob
Feb 22, 2003·CNS Drug Reviews·Patricia A SeymourDavid W Schulz
Sep 3, 2016·Nature Reviews. Neuroscience·Marloes J A G HenckensAlon Chen
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.