Abstract
The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like immunoreactivity (Fos-LI) in the trigeminal nucleus caudalis. The tachykinin NK1 receptor antagonist, GR205171 (100 micrograms/kg i.v.) and the N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (1 mg/kg i.v.) each inhibited expression of Fos-LI following electrical stimulation. The calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP8-37 (1.3 mg/kg i.v.), administered following rostral intracarotid infusion of mannitol to disrupt the blood-brain barrier, tended to reduce Fos-LI evoked by electrical stimulation, although this failed to reach statistical significance. Capsaicin (10 nmol in 0.1 ml), administered intracisternally, produced a bilateral expression of Fos-LI in the trigeminal nucleus caudalis. This expression was unaffected by the peripherally acting NK1 receptor antagonist, GR82334 (0.2 mg/kg i.v.) or CGRP8-37 (1.3 mg/kg i.v.). The centrally penetrant NK1 receptor antagonist, GR205171 (...Continue Reading
Citations
May 24, 2001·Current Opinion in Neurology·A May, P J Goadsby
Aug 29, 2000·Cephalalgia : an International Journal of Headache·R H KemperG J Ter Horst
Apr 3, 2001·Expert Opinion on Investigational Drugs·A May, P J Goadsby
Feb 24, 2006·Headache·Sigrid Schuh-HoferGuy Arnold
Sep 29, 2006·The European Journal of Neuroscience·A BergerotP J Goadsby
Mar 13, 2014·British Journal of Pharmacology·S E Erdener, T Dalkara
Oct 25, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Kelly L RogersLyn R Griffiths
May 12, 2006·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Jun 1, 2011·The Journal of Headache and Pain·Dimos D MitsikostasPeter J Goadsby
Aug 22, 2013·Expert Opinion on Drug Discovery·Sieneke LabruijereAntoinette Maassenvandenbrink
Dec 12, 2018·Neural Regeneration Research·Ning ChenLi He
Jun 3, 2011·Headache·Saurabh GuptaB Lee Peterlin
Dec 5, 2002·Current Medical Research and Opinion·N M Ramadan
May 3, 2008·Current Opinion in Neurology·Katharina Eikermann-Haerter, Michael A Moskowitz
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jul 28, 2009·Brain Research·Helle Wulf-JohanssonInger Jansen-Olesen