Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla neurons

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Christopher J MaddenA F Sved

Abstract

This study determined the effect of destruction of rostral ventrolateral medulla (RVLM)-C1 cells on integrated sympathetic and hormonal responses to hypotension or glucoprivation. Injection of anti-dopamine beta-hydroxylase-saporin into the RVLM resulted in 29-99% depletion of RVLM-C1 neurons and approximately 60% reduction in the number of A5 neurons. As in our previous study in unanesthetized rats, resting mean arterial pressure (MAP) was reduced by approximately 10 mmHg in rats with >80% depletion of RVLM-C1 cells compared with control rats, although resting heart rate (HR) did not differ significantly. In the present study, resting plasma levels of norepinephrine (NE) did not differ significantly between control rats and rats with >80% depletion of RVLM-C1 cells, although there was a tendency for RVLM-C1 lesioned rats to have lower levels. Also consistent with our previous study, hydralazine (HDZ)-evoked hypotension resulted in smaller increases in HR and plasma levels of NE in rats with >80% depletion of RVLM-C1 cells compared with control rats. Furthermore, the elevated plasma levels of posterior pituitary hormones vasopressin and oxytocin evoked by HDZ were blunted in RVLM-C1 lesioned rats compared with control rats, eve...Continue Reading

References

Dec 1, 1992·The American Journal of Physiology·A J Verberne, P G Guyenet
Feb 22, 1990·The Journal of Comparative Neurology·E T CunninghamP E Sawchenko
Feb 1, 1989·The American Journal of Physiology·R L StornettaD J Reis
Jul 1, 1988·The Journal of Endocrinology·H Hashemzadeh-GargariP G Guyenet
Apr 1, 1985·The American Journal of Physiology·A R GranataD J Reis
Apr 23, 1993·Brain Research·N KoshiyaP G Guyenet
Nov 15, 1997·The American Journal of Physiology·J C SchiltzA F Sved
Dec 31, 1997·The Journal of Comparative Neurology·A M Schreihofer, P G Guyenet
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Schreihofer, P G Guyenet
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A M Schreihofer, P G Guyenet
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S F Morrison, W H Cao
Feb 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W HuangA F Sved
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W H Cao, S F Morrison
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Christopher J Madden, Alan F Sved
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Feb 25, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved

❮ Previous
Next ❯

Citations

Aug 14, 2012·American Journal of Physiology. Heart and Circulatory Physiology·M M J FarnhamP M Pilowsky
Nov 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C J Madden
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ai-Jun LiSue Ritter
Feb 1, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kate Benincasa HerrLeszek Kubin
May 15, 2012·Autonomic Neuroscience : Basic & Clinical·Anthony J M Verberne, Michael P Gilbey
May 18, 2010·Respiratory Physiology & Neurobiology·Melissa M J Farnham, Paul M Pilowsky
Mar 5, 2016·Neurochemical Research·Manjula SenthilkumaranLarisa Bobrovskaya
Nov 26, 2008·Molecular and Cellular Endocrinology·Erick A BourassaRobert C Speth
Jun 15, 2007·The Journal of Comparative Neurology·B J KangR L Stornetta
Jul 6, 2014·The Journal of Comparative Neurology·Genrieta BochorishviliPatrice G Guyenet
Jun 7, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ai-Jun LiSue Ritter
Aug 24, 2018·The Journal of Comparative Neurology·M SenthilkumaranI J Llewellyn-Smith
Jan 29, 2019·Endocrine Reviews·Sarah StanleyElizabeth R Seaquist
Apr 29, 2008·The Journal of Physiology·Ana C TakakuraPatrice G Guyenet
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter G R BurkeAnn K Goodchild
May 24, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrice G GuyenetStephen B G Abbott
Sep 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·Adele RomanoSilvana Gaetani
Apr 24, 2019·American Journal of Physiology. Endocrinology and Metabolism·Zohra M KakallPaul M Pilowsky
Jun 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ai-Jun LiSue Ritter
Sep 3, 2010·American Journal of Physiology. Endocrinology and Metabolism·A J M Verberne, D M Sartor
Oct 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard C RogersGerlinda E Hermann
Apr 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Melissa A InglottPaul M Pilowsky
Mar 29, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard C RogersGerlinda E Hermann
Oct 4, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zohra M KakallPaul M Pilowsky
Oct 29, 2017·Experimental Physiology·Ruth L Stornetta, Patrice G Guyenet
Jul 1, 2020·Hypertension·Patrice G GuyenetVirginia L Brooks
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shayne F AndrewSue Ritter
May 26, 2018·Molecular Neurobiology·A J López-GamberoF Nualart
Dec 1, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zohra M KakallPaul M Pilowsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.