PMID: 4900146Oct 25, 1969Paper

Attenuation of human influenza A viruses

British Medical Journal
A S Beare, M L Bynoe

Abstract

The attenuation of two human influenza A viruses has been carried out, using the selection of inhibitor-resistant strains and multiple passages at low temperatures. A virus related to A2/Tokyo/3/67 was obtained in an inhibitor-resistant form. When this was compared with the inhibitor-sensitive strain in a volunteer trial it was relatively non-pathogenic. The second virus, A2/Hongkong/1/68, was subjected to much longer treatment, but nevertheless remained slightly sensitive to serum inhibitor. When given to volunteers it was less pathogenic than before but attenuation was incomplete. A2/Hongkong/1/68 was also modified by passage at low temperatures. Many of these passages are apparently necessary for full attenuation.All attenuated viruses were infective and antigenic.

Citations

Jan 1, 1970·Archiv für die gesamte Virusforschung·H Willers, A S Beare
Jan 1, 1973·Archiv für die gesamte Virusforschung·S R Mostow, D A Tyrrell
Oct 24, 2002·Journal of Virological Methods·B C E P D OliveiraM C Cabral
May 12, 2001·Vaccine·M D Wareing, G A Tannock
Aug 21, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Amy B SmithDean E Willis
Aug 1, 1977·Australian and New Zealand Journal of Medicine·J S Mackenzie
Oct 5, 1974·British Medical Journal
Jan 1, 1974·Postgraduate Medical Journal·C Stuart-Harris
Jun 1, 1976·Postgraduate Medical Journal·A S Beare
Apr 19, 2013·Clinical and Experimental Vaccine Research·Yo Han Jang, Baik-Lin Seong

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